Management of Childhood Brain Tumors: Consensus Report by the Pediatric Hematology Oncology (PHO) Chapter of Indian Academy of Pediatrics (IAP)

Bhat, Sunil; Yadav, Satya Prakash; Suri, Vaishali; Patir, Rana; Kurkure, Purna; Kellie, Stewart J.; Anupam, Sachdeva

doi:10.1007/s12098-011-0421-1

Cited by 6 publications

(4 citation statements)

References 61 publications

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“…Close collaboration between various regional groups should be recommended to promote multispecialty care, to improve standards of care and to bring out consensus guidelines for management of various tumors. [12,13] It will need joint collaborative steps by physicians, researchers, epidemiologists, administrators, support groups, and all individuals dedicated to the effective treatment of childhood cancer in India.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Suhag

Vats

et al. 2017

Indian J Med Paediatr Oncol

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Introduction:Pediatric tumors are a heterogeneous group of malignant conditions requiring multimodal treatment, and management of such cases is at time challenging. We present the clinical profile of pediatric cancer patients who received radiation, either alone or as adjuvant to surgery and chemotherapy; in prophylactic, radical or palliative clinical setting.Aim:This study was envisaged to review our experience of pediatric oncology cases, their clinical and morphological profile, dosage schedule of radiotherapy, and the therapy induced complications.Settings and Design:This was a retrospective, observational study carried out in an apex tertiary care cancer institute of government set-up in a developing country.Materials and Methods:The treatment charts and clinical summary of patients who had received radiation over the last 5 years period were retrieved and perused. Various clinical and pathological parameters were studied and inferences drawn.Results:A total of 50 patients got radiation over 5 year study-period, including 37 male and 13 female patients. The commonest age group of presentation was 8-12 years followed by 13-16 years. The mean age of presentation was 9.3 years. The most common diagnosis was hematological malignancies followed by CNS tumors with 21 and 13 patients respectively. Overall the most common indication of RT was in adjuvant setting after surgery as the definitive management, where 24 patients were irradiated; and the next common indication was prophylactic cranial irradiation in 14 patients of childhood leukemias. 10 patients tolerated treatment with Grade 1 site-specific or systemic toxicities while 7 patients developed Grade 2 and more systemic toxicities. 9 patients received craniospinal irradiation, common indications being medulloblastoma and Atypical teratoma rhabdoid tumor (ATRT). 3 patients received concurrent chemotherapy with weekly Inj Vincristine. 17 patients required sedation or short general anaesthesia for radiation planning and execution.Conclusion:External beam Radiotherapy constitutes an important component of management of pediatric cancers. One should be judicious in Radiotherapy planning, execution and monitoring acute and delayed toxicities.

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Section: Discussionmentioning

confidence: 99%

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Suhag

Vats

et al. 2017

Indian J Med Paediatr Oncol

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“…To promote mutlispecialty care and improve standards of care, PHO chapter of IAP has held various meetings to bring out consensus guidelines for management of various tumors. The first such publication has been on management of pediatric brain tumor with emphasis on multispecialty care [28].…”

Section: Lack Of Cooperative Groups and Multispecialty Carementioning

confidence: 99%

Barriers to Cure for Children with Cancer in India and Strategies to Improve Outcomes: A Report by the Indian Pediatric Hematology Oncology Group

Yadav

Rastogi

Kharya

et al. 2014

Pediatric Hematology and Oncology

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The survival of children with cancer in India is inferior to that of children in high-income countries. The Indian Pediatric Hematology Oncology Group (IPHOG) held a series of online meetings via www.Cure4kids.org to identify barriers to cure and develop strategies to improve outcomes. Five major hurdles were identified: delayed diagnosis, abandonment, sepsis, lack of co-operative groups, and relapse. Development of regional networks like IPHOG has allowed rapid identification of local causes of treatment failure for children with cancer in India and identification of strategies likely to improve care and outcomes in the participating centers. Next steps will include interventions to raise community awareness of childhood cancer, promote early diagnosis and referral, and reduce abandonment and toxic death at each center. Starting of fellowship programs in pediatric hemato-oncology, short training programs for pediatricians, publishing outcome data, formation of parent and patient support groups, choosing the right and effective treatment protocol, and setting up of bone marrow transplant services are some of the effective steps taken in the last decade, which needs to be supported further.

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“…The older age of the children also linked to PSIs. This duration is observed to be longer in patients suffering from convulsions as well [16][17] .…”

Section: Discussionmentioning

confidence: 92%

Lag Time of Pediatric Supra Tentorial Brain Tumors in Lower Middle Income Countries (LMIC)

Alavi¹,

Goraya²,

Ahmed³

et al. 2022

PJMHS

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Background: The most common and frequent tumors in the children’s are central nervous system tumors (CNS). Objective: For evaluation of the lag time and clinical spectrum of pediatric supratentorial brain tumors from the time of appearance of symptoms in a patient to the time the patient presents to the hospital. Study design: It is an observational and cohort study conducted in the radiology and oncology department of our institute teaching hospital. Material and Methods: This prospective research was conducted at the oncology department of the children hospital ICH Lahore for one year. The study was approved by the IRB. The duration of the study was from March 2021 to March 2022. The sample size was calculated. The patients of age range between 0 months to 17 years were included in the study. SPSS version 24.0 was used for statistical analysis. Data will be stratified to see the effect modulators. Results: This study included 60 patients 30 girls and 30 boys. The average age of the patients at the time they were diagnosed with pediatric supratentorial brain tumor was 7 years. The majority of the patients reported to have type I neurofibromatosis. Some of the most common symptoms that the patients reported were vomiting, oculo-visual issues, motor problems, headache and endocrine dysfunction. Conclusion: The lag time and clinical spectrum of pediatric supratentorial brain tumors from the time of appearance of symptoms in a patient to the time the patient presents to the hospital was reported to be 2-6 months in majority almost 61% of the children. The 71% children visited the two regional area doctors before visiting the tertiary care hospital. The complex interplay of underdiagnoses, unavailability of the neuro-oncology treatments facilities and higher rates of abandonment in the LIMC are the basic reason behind survival gaps of the delayed presented patients. Keywords: Pediatric supratentorial brain tumors, lag time, low/middle income countries (LMIC), Central nervous system (CNS) tumors and intraxial tumors.

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Management of Childhood Brain Tumors: Consensus Report by the Pediatric Hematology Oncology (PHO) Chapter of Indian Academy of Pediatrics (IAP)

Cited by 6 publications

References 61 publications

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Barriers to Cure for Children with Cancer in India and Strategies to Improve Outcomes: A Report by the Indian Pediatric Hematology Oncology Group

Lag Time of Pediatric Supra Tentorial Brain Tumors in Lower Middle Income Countries (LMIC)

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