Management of choroidal metastases

Jardel, P.; Sauerwein, W.; Olivier, Timothée; Bensoussan, E.; Maschi, C.; Lanza, Francesco; Mosci, Carlo; Gastaud, Lauris; Angellier, G.; Marcy, Pierre-Yves; Hérault, J.; Caujolle, Jean‐Pierre; Dendale, R.; Thariat, Juliette

doi:10.1016/j.ctrv.2014.09.006

Cited by 68 publications

(58 citation statements)

References 55 publications

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“…In a systemic review, 4-12 % of all malignant intraocular lesions were revealed to be choroidal metastases [3]. Our case is consistent with the literature insofar as breast cancer is the most common primary tumor of uveal metastases in women [4].…”

Section: Discussionsupporting

confidence: 90%

An Unusual Case of “Red Eye”

Janeschitz‐Kriegl

Meyer

Scholl

et al. 2019

Klin Monatsbl Augenheilkd

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Section: Discussionsupporting

confidence: 90%

An Unusual Case of “Red Eye”

Janeschitz‐Kriegl

Meyer

Scholl

et al. 2019

Klin Monatsbl Augenheilkd

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“…The fenestrated choroidal vascular plexus accounts for the highest blood flow rate by weight of any tissue in the body . The blood vessels that supply the choroid, mainly the posterior ciliary arteries, are localised to the posterior pole and are thought to enable greater access of tumour emboli into the choroid . Approximately 66 per cent of patients with choroidal metastasis have a prior history of cancer, most commonly the breast in women and the lungs in men .…”

Section: Discussionmentioning

confidence: 99%

Multimodal imaging of suspicious choroidal neoplasms in a primary eye‐care clinic

Kaur

Anthony

2017

Clinical and Experimental Optometry

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Small suspicious choroidal neoplasms commonly present a diagnostic challenge in primary eye-care clinics, where they are most likely to present. Differentiating benign from malignant choroidal neoplasms is essential for facilitating early diagnosis and treatment, potentially decreasing the risk of metastasis and vision loss in some cases. The purpose of this review is to describe the clinical, spectral-domain optical coherence tomography and fundus autofluorescence features of suspicious choroidal neoplasms in a case series of patients presenting to a primary eye-care clinic at the Veterans Health Administration, Cleveland, Ohio, USA.Key words: benign choroidal neoplasm, choroidal melanoma, choroidal metastasis, choroidal naevus, fundus autofluorescence, optical coherence tomography, sclerochoroidal calcification Primary eye-care providers are likely to encounter patients with suspicious choroidal lesions during routine clinical examination. The choroid can be a harbour of malignant neoplasms, such as choroidal melanoma and metastasis.1 Other benign choroidal lesions may have overlapping clinical features that mimic malignancies, many times precluding an accurate diagnosis and requiring consultation with a retinal or ocular oncology ophthalmologist. With access to high-resolution spectral-domain optical coherence tomography (SD-OCT), optometrists are able to evaluate microstructural retinal and choroidal changes, allowing better characterisation of suspicious choroidal lesions. SD-OCT is also used to perform enhanced-depth imaging OCT (EDI-OCT) to increase the resolution of structures posterior to the retinal pigment epithelial (RPE) layer, specifically the choroid and sclera, further expanding the ability to evaluate subretinal lesions. Fundus autofluorescence is another useful imaging tool for evaluating retinal changes associated with choroidal lesions. Fundus autofluorescence highlights the presence of lipofuscin, a clinical finding known to have strong association with malignant choroidal lesions. SD-OCT systems such as Topcon 3D OCT-2000 (Topcon Medical Systems, Inc., Oakland, New Jersey, USA) and Heidelberg Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg, Germany) are equipped with fundus autofluorescence imaging, which is able to highlight areas of RPE distress caused by the underlying effects of invasive or spaceoccupying choroidal lesions. Combined analysis of SD-OCT and fundus autofluorescence, referred to as multimodal imaging, can enhance the evaluation process for suspicious choroidal lesions, possibly facilitating an earlier diagnosis and conversely, preventing false-positive referrals for benign choroidal lesions. Herein, we describe the clinical, SD-OCT and fundus autofluorescent features of small suspicious choroidal neoplasms and mimicking lesions, both benign and malignant, in a case series of patients presenting to a primary eye-care clinic at the Veterans Health Administration, Cleveland, Ohio, USA. METHODSof the choroidal neoplasm was plotted manually at the location judged to b...

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“…To date, radiotherapy remains the treatment of choice of choroidal metastases: long experience and good results are reported in the literature [9].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Choroidal Metastasis as Initial Presentation of Parotid Gland Adenoid Cystic Carcinoma

Mouzari¹,

Chekhchar²,

Aitelhaj³

et al. 2017

mmunol Disord Immunother

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Choroidal metastasis rarely reveals a primary cancer. At this stage, they are associated with multiple metastases. Adenoid cystic carcinoma also known as cylindroma is very rare and constitutes 1% of major and minor salivary glands malignancies. In the parotid gland, the ACC is relatively rare, constituting only 2-3% of all tumors. The purposes of this study are to report the first case of parotid gland adenoid cystic carcinoma metastatic to the choroid and discuss treatment approaches. The systemic prognosis of salivary gland ACC is poor, with frequent local recurrences and late distance metastases. Even though uncommon, ocular metastases should be considered, and plaque radiotherapy may be useful to treat these patients.

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Management of choroidal metastases

Cited by 68 publications

References 55 publications

An Unusual Case of “Red Eye”

An Unusual Case of “Red Eye”

Multimodal imaging of suspicious choroidal neoplasms in a primary eye‐care clinic

Bilateral Choroidal Metastasis as Initial Presentation of Parotid Gland Adenoid Cystic Carcinoma

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