Management of Chronic Cholestasis in Childhood

Delayed Postnatal Presentation of Biliary Atresia in 2 Premature Neonates

“…In both preterm babies, stools became acholic at a time corresponding to a normal term birth (corrected age: 1 day). This is in accordance with previous data, which showed that in normal‐term babies with BA, stools became acholic within 2 weeks after birth (17). The third trap that has been avoided was to interpret favorably the decrease in total serum bilirubin concentration, whereas the proportion of conjugated bilirubin increased signing cholestasis.…”

Parenteral nutrition–associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review

“…However, cholestasis as a result of long-term lipid administration is widely accepted as a precursor to PNAC [28,29]. The use of soybean-based intravenous lipid emulsions (SLEs) has been speculated to be a contributing factor in the development of PNAC.…”

Neonatal Sclerosing Cholangitis in Two Siblings

“…External diversion of bile may alleviate pruritus and halt progress of liver disease in some cases (16). With paucity of interlobular bile du ct s , progressiv e liver damage occurs in 26% of patients with sy ndromic features a nd 55% of patients without (17,18).…”