2008
DOI: 10.1007/s10787-008-1623-7
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Management of chronic musculoskeletal pain in the Elderly: Opinions on oral medication use

Abstract: The use of oral medication in the treatment of chronic musculoskeletal pain in the elderly requires careful selection of drugs to control pain with consideration for both the physiological state and the presence of disease(s). Recent advances have improved the understanding of biomolecular mechanisms of chronic pain. These include the production of powerful pro-inflammatory cytokines by glial and microglial cells, which then lead to activation of major pain pathways from the periphery through the dorsal horn a… Show more

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Cited by 49 publications
(66 citation statements)
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“…The most commonly prescribed drugs were systemic and/or local NSAIDs. It has been established that NSAIDs are useful in chronic musculoskeletal pain, but the incidence of musculoskeletal disorders increases with age, and this is in parallel with the increased risk of adverse effects to the NSAIDs (16,17). Moreover, our findings indicate that pharmacological interventions for multiple musculoskeletal diseases make a remarkable contribution to the polypharmacy in elderly.…”
Section: Discussionmentioning
confidence: 61%
“…The most commonly prescribed drugs were systemic and/or local NSAIDs. It has been established that NSAIDs are useful in chronic musculoskeletal pain, but the incidence of musculoskeletal disorders increases with age, and this is in parallel with the increased risk of adverse effects to the NSAIDs (16,17). Moreover, our findings indicate that pharmacological interventions for multiple musculoskeletal diseases make a remarkable contribution to the polypharmacy in elderly.…”
Section: Discussionmentioning
confidence: 61%
“…APAP is usually the first choice because it is relatively safe for older people. It was reported that APAP treatment reduced pain behaviors associated with musculoskeletal pain in persons with dementia in community-dwelling [45,46]. Dosing of APAP should be limited to avoid liver toxicity, and topical analgesics are preferred for focal pain.…”
Section: Nonopioidsmentioning
confidence: 99%
“…According to the 2009 guidelines for pharmacologic management of persistent pain in older persons published by the AGS, NSAIDs should be used only with extreme caution in highly selected individuals once other safer therapies have failed. Absolute contraindications for NSAIDs use in older adults are chronic kidney disease, heart failure, and active peptic ulcer disease [16,46,49].…”
Section: Nonopioidsmentioning
confidence: 99%
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