2021
DOI: 10.3389/fonc.2021.674253
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Management of Clinically Involved Lateral Lymph Node Metastasis in Locally Advanced Rectal Cancer: A Radiation Dose Escalation Study

Abstract: BackgroundPatients with lateral lymph nodes (LLNs) metastasis are not effectively treated with neoadjuvant chemoradiotherapy. This study aimed to compare the efficacy of three neoadjuvant therapeutic regimens, namely, chemotherapy, chemoradiotherapy, and chemoradiotherapy with a dose boost of LLNs, and to identify the optimal approach for treating LLNs metastasis of locally advanced rectal cancer.MethodsA total of 202 patients with baseline LLNs metastasis (short axis ≥5 mm) and treated with neoadjuvant treatm… Show more

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Cited by 5 publications
(2 citation statements)
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“…LLR rates were 2.3%, 31.6%, and 20.4%, respectively. 28 Another study compared 78 patients with simultaneous integrated boost to LLNs and the primary tumor (total dose of 55 Gy) to 94 patients without LLNs (71 received 55 Gy to primary tumor, 23 received 25 Gy). 29 Five-year local control rate was significantly better in the boost group (97% vs 86%, P = .026).…”
Section: Discussionmentioning
confidence: 99%
“…LLR rates were 2.3%, 31.6%, and 20.4%, respectively. 28 Another study compared 78 patients with simultaneous integrated boost to LLNs and the primary tumor (total dose of 55 Gy) to 94 patients without LLNs (71 received 55 Gy to primary tumor, 23 received 25 Gy). 29 Five-year local control rate was significantly better in the boost group (97% vs 86%, P = .026).…”
Section: Discussionmentioning
confidence: 99%
“…However, LPLD extends surgical time and blood loss volume, and it may also affect urinary and sexual function [12] . If the radiotherapy dose can be increased by new radiotherapy techniques, it can improve the LPLN regression without increasing treatment-related toxicity [18,43] . In our center, the SIB-IMRT technique has been used to treat LPLN-positive patients, and the results demonstrated better e cacy and safety [16,17] .…”
Section: Discussionmentioning
confidence: 99%