Management of Complicated Urinary Tract Infection

Pang, Ruoming; Deng, Jianhua; Zhou, Xinyao

doi:10.5772/intechopen.74556

Urinary Tract Infection - The Result of the Strength of the Pathogen, or the Weakness of the Host 2018

DOI: 10.5772/intechopen.74556

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Management of Complicated Urinary Tract Infection

Ruoming Pang¹,

Jianhua Deng²,

Xinyao Zhou³

Abstract: The management of complicated urinary tract infection (UTI) remains a challenge since the coexisted conditions may significantly decrease the successful rate of treatment. In this chapter, the specific conditions including indwelling catheter, urolithiasis, neurogenic bladder, vesicoureteral reflux and pregnancy are listed. In terms of each condition, the potential influence on UTI and management strategy is discussed. Not only is the current evidence reviewed but also we present our experience on management o… Show more

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2023

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Cited by 1 publication

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Modern Combined Treatment of Acute Complicated Cystitis in Women

Davidov,

Meltsina,

Bunova

et al. 2023

Vrach

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One of the most common human diseases is acute cystitis, which affects mainly women. Annually in Russia there are 26-36 million cases of acute cystitis. The most severe contingent is considered to be patients with acute complicated cystitis, whose treatment efficiency is only 64.6–85.8% or less. Objective. Evaluation of the analgesic effect, efficacy and tolerability of phenazopyridine in combination with the antibiotic cefixime for the treatment of acute complicated cystitis in women of working age. Material and methods. A multicenter randomized open study of phenazopyridine in combination with the antibiotic cefixime in the treatment of 144 women with an average age of 42.2±3.8 years with acute complicated cystitis was performed in 5 polyclinics of the Perm region. In 55.6% of patients, the risk factors were not urological, but therapeutic and gynecological diseases. The international scale of cystitis ACSS, visual analogue scale (VAS) of pain, laboratory and bacteriological methods were used. The main group consisted of 72 women who received oral phenazopyridine (Urinalgin F) at a dose of 200 mg 3 times a day for 2 days and cefixime 400 mg 1 time per day for 7 days. The comparison group consisted of 72 women who received orally cefixime at the same dose for 7 days and No-spa (drotaverine hydrochloride) 80 mg 3 times a day for 2 days. Results. In the main group, a strong analgesic and antidysuric effect of phenazopyridine was noticed, which was confirmed by the analysis of the ACSS and VAS scales. Already after 20 minutes, an analgesic effect was detected, after 2 days pain symptoms and dysuria completely disappeared in 70 (97.2%) patients, despite the high initial level. The pain index on the VAS scale decreased from the initial 6.5 points to 0.03 points, i.e. by 217 times. The clinical efficacy (recovery) of combination therapy with phenazopyridine and cefixime was 91.7%, bacteriological efficacy was 91.8%, leukocyturia disappeared earlier, and the period of temporary disability decreased by 28.6%. In the comparison group, clinical (83.3%) and bacteriological (83.6%) efficiency was lower. Urinalgin F showed a favorable safety profile, only 1 (1.4%) patient had a side effect (nausea). Conclusion. Phenazopyridine (Urinalgin F) is a drug with high effectiveness and tolerability that eliminates pain, dysuria and other symptoms of acute complicated cystitis, eliminates leukocyturia earlier and more significantly, and reduces the period of temporary disability by 28.6%. Combined therapy of acute complicated cystitis with the antibiotic cefixime and the selective analgesic Urinalgin F has a high clinical and bacteriological efficacy.

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Modern Combined Treatment of Acute Complicated Cystitis in Women

Davidov,

Meltsina,

Bunova

et al. 2023

Vrach

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show abstract

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Management of Complicated Urinary Tract Infection

Cited by 1 publication

References 52 publications

Modern Combined Treatment of Acute Complicated Cystitis in Women

Modern Combined Treatment of Acute Complicated Cystitis in Women

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