2022
DOI: 10.21037/cco-21-90
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Management of complications from brain metastasis treatment: a narrative review

Abstract: Objective: To describe the range of potential side effects associated with modern brain metastasis treatment and provide evidenced-based guidance on the effective management of these side effects.Background: Brain metastases are the most commonly diagnosed malignant intracranial tumor and have historically been associated with very poor prognosis. The standard treatment for brain metastases until the 1990s was whole-brain radiation therapy (WBRT) alone. Since then, however, numerous advances have established t… Show more

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Cited by 4 publications
(3 citation statements)
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References 146 publications
(171 reference statements)
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“…Local treatments, such as surgical resection and radiotherapy, provide survival benefit for patients [ 13 , 14 ]. However, the neurological complications associated with intracranial malignancy and associated treatments negatively impact patients’ quality of life such as fatigue, headaches, neurocognitive decline, and focal neurology [ 15 , 16 ]. Early detection and treatment of intracranial disease result in improved post-intervention status [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Local treatments, such as surgical resection and radiotherapy, provide survival benefit for patients [ 13 , 14 ]. However, the neurological complications associated with intracranial malignancy and associated treatments negatively impact patients’ quality of life such as fatigue, headaches, neurocognitive decline, and focal neurology [ 15 , 16 ]. Early detection and treatment of intracranial disease result in improved post-intervention status [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…One of the first treatments for BM was whole-brain radiation therapy (WBRT). Other important local therapy options available today include stereotactic radiosurgery (SRS) and neurosurgical resection [ 13 ]. Surgical resection followed by radiotherapy (RT) could be curative for a small, solitary BM [ 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, the current treatment options for patients with extracranial disease and/or multiple BM remain mainly palliative [ 6 ]. Most recently, targeted systemic therapies and immunotherapy appeared in the multidisciplinary management of BM, leading to an improvement in intracranial control, survival, and neurocognitive preservation among these patients [ 13 ].…”
Section: Introductionmentioning
confidence: 99%