Management of Concurrent Severe Preeclampsia and Thrombotic Thrombocytopenic Purpura (TTP)

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a devastating disease involving the micro circulating (capillary wall damage) of multiple organs and could be seriously fatal if not diagnosed and treated promptly [1]. TTP is a rare complication of pregnancy with a poor prognosis and high fetal mortality, especially when it occurs during the first trimester [2]. But most of TTP cases occur in the late trimester of pregnancy. Untreated TTP is associated with more than 90% mortality rate [3]. Plasma replacement, even in pregnancy, remains as the corner stone of prevention and treatment of TTP, especially those with autoantibody-driven ADAMTS-13-deficient TTP [4].