Management of congenital choanal atresia: A pedodontist′s role

Abstract

Choanal atresia is a rare cryptic congenital anomaly with developmental failure of the nasal cavity to communicate with the nasophaynx, resulting in a significant physiological and anatomical alteration of the dento-facial complex. It is considered as a life-threatening or lethal congenital malformation in an obligatory nasal breathing neonate. Elective transnasal endoscopic repair is the most preferred and minimally invasive procedure to correct this anomaly. This case report describes the multi-disciplinary team approach that included pedodontists to manage the case of a 6-month-old infant with choanal atresia suffering from breathlessness, feeding difficulty, and disturbed sleep.

An Update of the Use of Thiocarbohydrazides and Thiosemicarbazides in the Preparation of Heterocycles and Their Biological Importance

“…In two step reactions, hydrazinolysis of substituted methyl benzoates gave acid hydrazides 7 which, on addition to CS 2 , sodium monochloroacetate (8) and hydrazine hydrate afforded benzamidothiosemicarbazides (N-aroyl thiocarbohydrazides (9a-c (Scheme 7) [14].…”

“…It was reported that a mixture of 3- dene)amino]thiourea derivatives 15a-j (43-56%) and N 0 ,2bis(2-oxoindolin-3-ylidene)-hydrazine-1-carbothiohydrazine (16) (20-31%), was effectively obtained by the reaction between (substituted-ylidene) thiocarbonohydrazides 13a-j with isatin malononitrile (14) with stirring at r.t in absolute ethanol and few drops of piperidine (Scheme 9) [16].…”

“…Substituted aminothiadiazolylhydrazono-indolin-2-ones 36a-d were prepared in 89-94% yields, when equimolar amounts of 2-(hydrazinecarbonothioyl)-N-substituted-hydrazinecarbo thioamides 35a-d and 2-(dicyanomethylene)-2-indolone (14) were stirred in ethanol with catalytic amount of piperidine at room temperature (Scheme 19) [26].…”