Management of coronary artery disease: therapeutic options in patients with diabetes

Hammoud, Talal; Tanguay, Jean‐François; Bourassa, Martial G.

doi:10.1016/s0735-1097(00)00732-4

Cited by 231 publications

(131 citation statements)

References 113 publications

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“…The prevalence of diabetic patients in our group was high (33%) and did not relate to the alterations in markers after stent implan-tation, but the presence of this risk factor confirms which is reported in the literature: the negative influence of diabetes on the late prognosis of the patients with coronary atherosclerosis, elevating the risks of death, infarction, and other cardiac events 29,30 . Regarding to percutaneous interventions, the presence of diabetes does not impair clinical success; however, the rate of restenosis, even with the use of stents, is high, being attributed to exacerbated intimal hyperplasia.…”

Section: Incidence Of Intracardiac Thrombus and Thromboembolism In Thsupporting

confidence: 87%

Avaliação comparativa do valor prognóstico de quatro marcadores bioquímicos de lesão miocárdica pós intervenções percutâneas utilizando stents coronarianos

Centemero¹,

Sousa²,

Staico³

et al. 2004

Arq. Bras. Cardiol.

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The systematic assessment of total creatine kinase (total CK) and its MB subfraction (CK-MB) after percutaneous coronary intervention shows that 5% to 40% of the patients successfully treated have an elevation in the serum level of those enzymes, which may represent a certain degree of myocardial necrosis [1][2][3] . Recently, the analysis of other very sensitive biochemical markers specific for identifying myocardial damage (CK-MB mass, troponins T and I) has intensified the detection of that phenomenon, which has been much more frequently observed with the implantation of coronary stents 4,5 .This study aimed at establishing the clinical meaning of those alterations and their impact on the occurrence of adverse cardiac events. It also had the following objectives: 1) to assess the incidence of the elevations in the CK-MB activity and mass and in the levels of troponins T and I after elective coronary stenting; 2) to analyze the association between the elevation of the markers and clinical, angiographic, and technical variables, and periprocedure problems; 3) to determine the prognostic effect of the elevation of the 4 markers after intervention on the occurrence of death, myocardial infarction, and need for new revascularization procedures in a one-year period. MethodsThis prospective study comprised 199 consecutive patients from the coronary angioplasty unit at the Instituto Dante Pazzanese de Cardiologia. They underwent elective coronary stent implantation for the treatment of stenoses located in native coronary arteries from August 2001 to January 2002. The patients met the following inclusion criteria: both genders; no restriction regarding age; normal levels of CK-MB activity in the 24 hours preceding the intervention; patients with clinically controlled stable or unstable angina (no recurrence of pain in the 2 weeks preceding the percutaneous treatment, to reduce the chances of an elevation in the troponins before the procedure); asymptomatic patients with ischemia detected on functional tests; presence of luminal obstruction > 50% in one or more vessels, with primary lesions anatomically favorable to stent implantation; absence of severe left ventricular dysfunction (EF > 0.30); elective treatment with angiographic success at the end of the procedure.The exclusion criteria were as follows: renal failure (creatinine > 2.0 mg/dL); presence of comorbidities that could affect late ResultsChanges in the levels of the 4 markers after stent implantation are relatively frequent (6.1% to 32.8%) ConclusionSystematic monitoring of CK-MB activity after coronary stenting is justified due to its clinical and laboratory behavior reported in studies relating its elevation after the procedure to a worse late outcome, and due to its low cost.

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Section: Incidence Of Intracardiac Thrombus and Thromboembolism In Thsupporting

confidence: 87%

Avaliação comparativa do valor prognóstico de quatro marcadores bioquímicos de lesão miocárdica pós intervenções percutâneas utilizando stents coronarianos

Centemero¹,

Sousa²,

Staico³

et al. 2004

Arq. Bras. Cardiol.

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“…About three-fourths of deaths in persons with T2DM are a consequence of cardiovascular diseases [51,52]. The relative frequency of heart disease as a cause of death varies among Asian American ethnic groups.…”

Section: Assumption: Risk And/or Prevalence For T2dm Must Be the Samementioning

confidence: 99%

Errors Associated with Aggregating Asian American Ethnic Groups in Diabetes Research, Education, and Clinical Practice

Jordan¹,

Jordan²,

Yumul³

et al. 2017

ARC Journal of Diabetes and Endocrinology

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“…According to a theory, sinoatrial node is innervated by right vagal nerve and perfused with right coronary artery. Right coronary artery occlusion leads to destructive changes in parasympathetic fibers of the vagal nerve with resultant secondary otalgia [6][7][8][9].…”

Section: Case Reports In Otolaryngologymentioning

confidence: 99%

“…Though it very rarely presents with otalgia, it is still seldom seen with only otalgia without accompanying classical symptoms [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Left Side Otalgia Caused by Acute Myocardial Infarction

Chung¹,

Park²,

Choi³

2017

Korean J Otorhinolaryngol-Head Neck Surg

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Aim. To present a case referred to our clinic with severe right ear pain but without any abnormal finding during otological examination and diagnosed as myocardial infarction and also to draw attention to otalgia which can occur secondary to myocardial infarction. Case Report. An 87-year-old female admitted with right ear pain lasting for nearly 12 hours and sweating on the head and neck region. On otolaryngologic examination, any pathological finding was not encountered. Her electrocardiogram revealed findings consistent with myocardial infarction. Her troponin values were 0.175 ng/L at 1 hour, and 0.574 ng/L at 3 hours. The patient was diagnosed as non-ST MI, and her required initial therapies were performed. On cardiac angiography, very severe coronary artery stenosis was detected, and surgical treatment was recommended for the patient. The patient who rejected surgical treatment was discharged with prescription of medical treatment. Conclusion. Especially in elderly patients with complaints of ear pain but without any abnormal finding on otoscopic examination, cardiac pathologies should be conceived.

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Management of coronary artery disease: therapeutic options in patients with diabetes

Cited by 231 publications

References 113 publications

Avaliação comparativa do valor prognóstico de quatro marcadores bioquímicos de lesão miocárdica pós intervenções percutâneas utilizando stents coronarianos

Avaliação comparativa do valor prognóstico de quatro marcadores bioquímicos de lesão miocárdica pós intervenções percutâneas utilizando stents coronarianos

Errors Associated with Aggregating Asian American Ethnic Groups in Diabetes Research, Education, and Clinical Practice

Left Side Otalgia Caused by Acute Myocardial Infarction

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