Management of cutaneous adverse effects during treatment with ZD1839 in advanced non-small cell lung cancer (NSCLC): Surprising efficacy of early local treatment

Dermatologic side effects associated with the epidermal growth factor receptor inhibitors

“…10,25 Antihistamines such as hydroxyzine may provide relief for patients with pruritus. 25 Preliminary data from a trial with 0.025% alpha-hydroxy acid cream with 0.166% gentamicin and 0.122% betamethasone cream for grade 2 lesions showed improvement, 46 but the effectiveness of this combination treatment remains in question as the trial was uncontrolled. The use of topical antiacne medications such as retinoids and benzoyl peroxide has been questioned since the reaction has a different pathophysiology from acne vulgaris, 6,10 aside from being drying and irritating to the skin.…”

HER1/EGFR Inhibitor-Associated Rash: Future Directions for Management and Investigation Outcomes from the HER1/EGFR Inhibitor Rash Management Forum

“…For example, benzoyl peroxide should not be used, as this will aggravate dry skin. Alphahydroxy acids have been investigated in patients with grade 1 rash in a clinical trial [48]. Because the trial was uncontrolled, it is unclear whether the improvement noted was a result of the treatment or just the natural course of rash.…”

“…Because there are no controlled trials, the efficacy of all the agents is unproven. There are anecdotal reports of treatments, such as topical and systemic antibiotics, topical and systemic corticosteroids, retinoids, and antihistamines [5,20,24,41,[45][46][47], and one preliminary report from an uncontrolled trial of alpha-hydroxy acids with or without gentamicin and betamethasone [48]. While it is encouraging that rash treatment is being investigated, the lack of a control, especially since rash resolves spontaneously in many patients, means the effectiveness of this combination remains unclear and its use in the clinic cannot be recommended at this time.…”

Effets secondaires dermatologiques des inhibiteurs de l’EGFR

“…Les ré tinoïdes topiques n'ont pas d'efficacité . Le peroxyde de benzoyle et les AHA (Alpha-Hydroxy Acids) ont pu apporter un bé né fice dans certains cas [4,7,8,11] ; ils doivent ê tre prescrits avec pré caution car ils aggravent la xé rose cutané e. Les é ruptions modé ré es relè vent de traitements oraux par doxycycline (100 mg/jour), minocycline (100 mg/jour), ou lymé cycline (300 mg/jour) pendant au moins 3 mois. Les dermocorticoïdes sont modé ré ment efficaces, mais peuvent ê tre utilisé s pré cocement [12].…”