Management of drainage for malignant ascites in gynaecological cancer

Kietpeerakool, Chumnan; Rattanakanokchai, Siwanon; Jampathong, Nampet; Srisomboon, Jatupol; Lumbiganon, Pisake

doi:10.1002/14651858.cd007794.pub3

Cited by 10 publications

(6 citation statements)

References 61 publications

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“…The term ascites describes the pathologic accumulation of fluid within the peritoneal cavity [9]. Cirrhosis of the liver is the most common cause of ascites, but other conditions, such as heart failure, kidney failure, infection (such as tuberculosis), cancer, or gynecological malignancy can also cause this condition [10].…”

Section: Discussionmentioning

confidence: 99%

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Eamudomkarn

Likitdee

Kleebkaow

et al. 2020

Case Reports in Obstetrics and Gynecology

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Massive ascites as a presentation of endometriosis is a rare clinical entity that is most commonly seen in black nulliparous females. Herein, we describe a case of a 32-year-old multiparous Thai woman who presented with a two-year history of abdominal distension. Computerized tomography of the abdominopelvic region showed an infiltrative enhancing lesion involving the cul-de-sac and perirectal region with massive loculated ascites, suggesting carcinomatosis peritonei. Abdominal paracentesis was performed to yield fluid samples for evaluation, which revealed no malignant cells, and polymerase chain reaction (PCR) was negative for tuberculosis. The patient underwent exploratory laparotomy which revealed a large amount of serosanguinous ascites, thickened matted bowel loops, and necrotic debris covering the entire surface of the peritoneum and visceral organs. The surgical procedures included drainage of 6.5 liters of ascites, lysis adhesion, biopsy of the peritoneum, and right salpingo-oophorectomy. Histologic examination revealed benign endometrial glands with stroma at the peritoneum tissue and broad ligament. Other causes of ascites were excluded. The ascites responded to drainage and hormonal suppression. A final diagnosis of endometriosis was made based on these findings. Endometriosis should therefore be considered in differential diagnosis in women of childbearing age who present with ascites.

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Section: Discussionmentioning

confidence: 99%

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Eamudomkarn

Likitdee

Kleebkaow

et al. 2020

Case Reports in Obstetrics and Gynecology

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“…Cetuximab, an anti-epidermal growth factor receptor monoclonal antibody, is a standard option for the treatment of advanced cervical cancer (Meira et al, 2009). Fourteen drugs were identified, including catumaxomab, aldesleukin, trastuzumab, and ibritumomab tiuxetan, all of which have been confirmed for various cancers, including malignant ascites (Kietpeerakool et al, 2019), renal cell carcinoma (Fishman et al, 2019), gastric cancer (Kimura et al, 2018), and lymphoma (Lansigan et al, 2019), respectively. Among drug-interactions obtained, Staurosporine has been reported to target ZAP70 (Overington et al, 2006), but their interaction in cancer research is still blank.…”

Section: Discussionmentioning

confidence: 99%

Integrative Bioinformatics Approaches to Screen Potential Prognostic Immune-Related Genes and Drugs in the Cervical Cancer Microenvironment

Zhao

et al. 2020

Front. Genet.

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In developing countries, cervical cancer is still the major cause of cancer-related death among women. To better understand the correlation between tumor microenvironment (TME) and prognosis of cervical cancer, we screened 1367 differentially expressed genes (DEGs) of cervical cancer samples in The Cancer Genome Atlas (TCGA) database using Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm-derived immune scores. Then, we extracted 401 tumor immune microenvironment (TIME)-related DEGs that related to patients' survival outcomes. Protein-protein interaction (PPI) network and functional enrichment analysis revealed that the prognostic genes mainly participated in myeloid leukocyte activation, adaptive immune response regulation, and receptor signaling pathways. A total of 79 key prognostic DEGs were obtained through PPI network. A TF-lncRNA-miRNA-mRNA regulatory network was constructed to explore the potential regulatory mechanism. 4 genes (CCR7, PD-1, ZAP70, and CD28) were validated in another independent cohort of cervical cancer from the Gene Expression Omnibus (GEO) database. Finally, potential drugs for key prognostics DEGs were predicted using DrugBank. In conclusion, we obtained a list of potential prognostic TIME-related genes and potential predicted drugs by integrative bioinformatics approaches. A comprehensive understanding of prognostic genes within the TIME may provide new strategies for cervical cancer treatment.

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“…[ 8 ] For the various symptoms of UCEC, new treatment strategies are emerging. [ 9 , 10 ] At present, immunotherapy is the most popular due to its focus on targeting and mobilizing nonspecific immune cells, including NK cells and monocyte and macrophage lineages, resulting in cytotoxic functions in cancer tissues. This is especially important during postoperative adjuvant treatment as it reduces the risk of tumor recurrence.…”

Section: Introductionmentioning

confidence: 99%

LINC01589 serves as a potential tumor-suppressor and immune-related biomarker in endometrial cancer: A review

Chen

Wang

et al. 2023

Medicine

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Currently, increasing attention is being paid to biomarkers in endometrial cancer. Immune infiltration of the tumor microenvironment has been shown to significantly affect the overall survival (OS) of uterine corpus endometrial carcinoma (UCEC) patients. LINC01589 is a long non-coding RNA (lncRNA) that is rarely reported in cancer and is assumed to play a role in immune regulation. We therefore evaluated the role of LINC01589 in UCEC using the Cancer Genome Atlas (TCGA) database. We analyzed the expression of LINC01589 using the gene expression profiles of LINC01589 in the UCEC projects in TCGA. Comparisons between the differentially expressed genes (DEGs) of the cancer and adjacent normal tissues of the UCEC projects revealed that LINC01589 expression was decreased in UCEC tissues. A multivariate cox regression analysis indicated that LINC01589 upregulation could serve as an independent prognostic factor for survival. Furthermore, there was a positive correlation between LINC01589 expression and B cell, T cell, NK cell, monocytic lineage, and myeloid dendritic cell infiltration in UCEC patients. In addition, 5 clusters of hub genes were detected by comparison of different expression levels of LINC01589 in the UCEC groups. The analysis of the reactome pathway using gene set enrichment analysis (GSEA) revealed immune-related pathways, including CD22-mediated B cell receptor (BCR) regulation and antigen-activated BCRs, leading to the generation of second messengers and complement cascade pathways that were significantly enriched in the high LINC01589 expression group. Thus, LINC01589 may serve as a prognostic biomarker, as it is associated with immune infiltration in UCEC.

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Management of drainage for malignant ascites in gynaecological cancer

Cited by 10 publications

References 61 publications

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Integrative Bioinformatics Approaches to Screen Potential Prognostic Immune-Related Genes and Drugs in the Cervical Cancer Microenvironment

LINC01589 serves as a potential tumor-suppressor and immune-related biomarker in endometrial cancer: A review

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