2001
DOI: 10.1001/jama.285.10.1331
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Management of Dyspnea in Patients With Far-Advanced Lung Disease

Abstract: Dyspnea is a common problem among patients with interstitial fibrosis, lung cancer, cystic fibrosis, and chronic obstructive pulmonary disease. The slow but steady progression of such diseases, often punctuated by acute exacerbations or secondary illnesses, can lead to decision-making dilemmas among patients and their caregivers, such as when to accept mechanical ventilation, when to forgoe aggressive therapies, and when to make formal end-of-life care plans. Two cases, a 74-year-old woman with dyspnea seconda… Show more

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Cited by 65 publications
(10 citation statements)
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“…In end-stage disease, one option may also be to reduce ventilatory demand by decreasing the central drive with opiates. These have been shown to decrease minute ventilation at rest and during submaximal exercise, thus reducing the sensation of breathing and its associated anxiety [133]. There is also speculation that opiates act directly on opioid receptors in the airways [134].…”
Section: Drug Therapymentioning
confidence: 99%
“…In end-stage disease, one option may also be to reduce ventilatory demand by decreasing the central drive with opiates. These have been shown to decrease minute ventilation at rest and during submaximal exercise, thus reducing the sensation of breathing and its associated anxiety [133]. There is also speculation that opiates act directly on opioid receptors in the airways [134].…”
Section: Drug Therapymentioning
confidence: 99%
“…These can serve as valuable adjuncts to the expert analgesic and anxiolytic pharmacotherapy already required in this setting. In addition to paracentesis to mitigate abdominal discomfort, analogous use of thoracentesis for chest discomfort or dyspnea could be considered 11,26,27 . Further potential home‐based palliative or therapeutic uses include guidance of intravenous access 26,28 and assessment and incision of cutaneous abscesses.…”
Section: Discussionmentioning
confidence: 99%
“…Several of these articles have direct relevance to the clinical management of respiratory patients such as Mr LV. [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] These articles have been updated with recent evidence as a book and published as Care at the close of life: Evidence and experience. 47 Its 42 chapters are rich with examples of words that clinicians can utilize.…”
Section: Our Recommendationsmentioning
confidence: 99%