Management of end stage liver disease (ESLD): What is the current role of orthotopic liver transplantation (OLT)?

Miró, José M.; Laguno, Montserrat; Moreno, Asunción; Rimola, A.

doi:10.1016/j.jhep.2005.11.028

Cited by 45 publications

(31 citation statements)

References 43 publications

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“…5 Red blood cell transfusion requirements during surgery. 6 Table 2 shows the main characteristics of both cohorts. HCV/HIV-coinfected patients underwent the procedure in the same institutions and calendar year and, as matched criteria, they had a similar age and similar proportions of male gender, HBV coinfection and HCC as HCV-monoinfected recipients.…”

Section: Resultsmentioning

confidence: 99%

“…Information for each patient was recorded at registration on the OLT waiting list, every 3 months until OLT, and at OLT. After OLT data were recorded at 1,3,6,9,12,15,18,24,30, 36 months and annually thereafter for up to 10 years. Patient information was sent every 6 months to the coordinating center and entered into the FIPSE OLT-HIV-05-GESIDA 45-05 database (available at https://www.seif88.com/gesida/asp/login.asp).…”

Section: Definitions Data Collection Data Entry and Data Managementmentioning

confidence: 99%

“…5 Two HIV-infected patients and three HIV-negative recipients died after retransplantation. 6 Number of deaths (percentage related to the whole group).…”

Section: Post-olt Survival In Hcv/hiv-coinfected Patients and Hcv-monmentioning

confidence: 99%

“…Consequently, orthotopic liver transplantation (OLT) is increasingly necessary in this population (5). At present, HIV-infection is not an absolute contraindication for OLT (6), and this life-saving intervention is performed in most developed countries in selected HIV-infected patients with end-stage liver disease.…”

Section: Introductionmentioning

confidence: 99%

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Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study

Miró

Montejo

Castells

et al. 2012

American Journal of Transplantation

132

166

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Section: Resultsmentioning

confidence: 99%

Section: Definitions Data Collection Data Entry and Data Managementmentioning

confidence: 99%

“…5 Two HIV-infected patients and three HIV-negative recipients died after retransplantation. 6 Number of deaths (percentage related to the whole group).…”

Section: Post-olt Survival In Hcv/hiv-coinfected Patients and Hcv-monmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study

Miró

Montejo

Castells

et al. 2012

American Journal of Transplantation

132

166

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“…It is a major cause of death worldwide, and currently the only effective treatment is liver transplantation [Wang et al, 2003;Miro et al, 2006]. However, transplantation is limited by its high cost, a shortage of donor organs and the need for immunosuppression [Reding, 2005;Ochiya et al, 2010].…”

mentioning

confidence: 99%

Acute Hepatic Failure-Derived Bone Marrow Mesenchymal Stem Cells Express Hepatic Progenitor Cell Genes

Li¹,

Wu²,

Xin³

et al. 2011

Cells Tissues Organs

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Hepatic progenitor cell (HPC) transplantation is a promising alternative to liver transplantation for patients with end-stage liver disease. However, the precise origin of HPCs is unclear. This study aimed to determine whether bone marrow mesenchymal stem cells (BMSCs) isolated from rats in acute hepatic failure (AHF) possess hepatic potential and/or characteristics. BMSCs were isolated from normal rats as well as rats in which AHF was induced by D-galactosamine. HPCs and primary hepatocytes were isolated from normal rats for comparison. The Affymetrix GeneChip Rat Genome 230 2.0 Array was used to perform transcriptome profiling of the AHF-derived BMSCs and HPCs. The results showed that AHF-derived BMSCs had a gene expression profile significantly different from that of control BMSCs. More than 87.7% of the genes/probe sets that were upregulated more than 2-fold in AHF-derived BMSCs were expressed by HPCs, including 12 genes involved in liver development, early hepatocyte differentiation and hepatocyte metabolism. Confirmatory quantitative RT-PCR analysis yielded similar results. In addition, 940 probe sets/genes were expressed in both AHF-derived BMSCs and HPCs but were absent in control cells. Compared to the control cells, AHF-derived BMSCs shared more commonly expressed genes with HPCs. AHF-derived BMSCs have a hepatic transcriptional profile and express many of the same genes expressed by HPCs, strongly suggesting that BMSCs may be a resource for hepatocyte regeneration, and further confirming their potential as a strong source of hepatocyte regeneration during severe hepatic damage.

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Liver Transplantation: Prevention and Treatment of Infection

Bodro

Fernández

Moreno

2019

Evidence‐based Gastroenterology and Hepatology 4e

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Management of end stage liver disease (ESLD): What is the current role of orthotopic liver transplantation (OLT)?

Cited by 45 publications

References 43 publications

Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study

Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study

Acute Hepatic Failure-Derived Bone Marrow Mesenchymal Stem Cells Express Hepatic Progenitor Cell Genes

Liver Transplantation: Prevention and Treatment of Infection

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