MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

Mirza, Faryal; Canalis, Ernesto

doi:10.1530/eje-15-0118

Cited by 267 publications

(195 citation statements)

References 266 publications

(237 reference statements)

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“…The bone anatomy and endocrine system function could have influenced MC visibility. 26 It is interesting to know that we could not find any analogous studies confirming MC border visibility in relation to the region of each JDS and related regions.…”

Section: Discussionmentioning

confidence: 67%

Descriptive study of mandibular canal visibility: morphometric and densitometric analysis for digital panoramic radiographs

Kubilius¹,

Kubilius²,

Varinauskas³

et al. 2016

Dentomaxillofacial Radiology

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Objectives: To assess the visibility of the mandibular canal (MC) morphology in different jaw dental segments (JDSs) in relation to morphometric and densitometric parameters on digital panoramic radiographs (DPRs). Methods: 32 DPRs (155 JDSs) were selected randomly after retrieval. MC visibility in conjunction with superior and inferior border visibility was scored on a 5-point scale in four places on the JDS-that is, for the medial, distal, superior and inferior MC parts. Morphometric and densitometric analyses were made horizontally and vertically in the JDS region. Descriptive statistics, Fisher's exact test, Mann-Whitney U test and additional tests were performed. Results: There was no significant difference in MC visibility for the superior, inferior, medial and distal parts of the JDSs. Statistically significant (p , 0.05) differences were identified between particular visibility scores of the superior and inferior MC borders. In 22.0-24.7% of JDSs, the superior MC border was not visible, more than twice as often as the inferior MC border was not visible (9.1-10.2%). The visibility of superior and inferior MC borders in JDSs was not related to the morphometric or densitometric assessment parameters, or to age, gender, JDS location, condition or the visibility of neighbouring MC parts or contralateral JDSs. Conclusions: DPRs failed to provide MC visibility based on a single factor. Particular differences were identified between the levels of visibility of the superior and inferior MC borders. More advanced radiological investigation methods could be required for the evaluation of about 25% of JDSs when superior MC border identification is obligatory.

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Section: Discussionmentioning

confidence: 67%

Descriptive study of mandibular canal visibility: morphometric and densitometric analysis for digital panoramic radiographs

Kubilius¹,

Kubilius²,

Varinauskas³

et al. 2016

Dentomaxillofacial Radiology

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“…Due to increased receptor activator of nuclear factor kappa-B ligand production by the bone marrow stromal cells, and an increased degradation of osteoprotegerin, there is increased osteoclast precursor differentiation and consequently, enhanced bone resorption. [42] MM-derived mesenchymal stem cells produce osteoblasts that are different from healthy osteoblasts produced by normal mesenchymal stem cells. This may indicate that the progression of MM is independent of osteoporosis, which may be a by-product of the bone carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Risk of vertebral compression fractures in multiple myeloma patients

2017

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The purpose of this study was to develop and validate a finite element (FE) model to predict vertebral bone strength in vitro using multidetector computed tomography (MDCT) images in multiple myeloma (MM) patients, to serve as a complementing tool to assess fracture risk. In addition, it also aims to differentiate MM patients with and without vertebral compression fractures (VCFs) by performing FE analysis on vertebra segments (T1–L5) obtained from in vivo routine MDCT imaging scans. MDCT-based FE models were developed from the in vitro vertebrae samples and were then applied to the in vivo vertebrae segments of MM patients (n = 4) after validation. Predicted fracture load using FE models correlated significantly with experimentally measured failure load (r = 0.85, P < 0.001). Interestingly, an erratic behavior was observed in patients with fractures (n = 2) and a more gradual change in FE-predicted strength values in patients without fractures (n = 2). Severe geometric deformations were also observed in models that have already attained fractures. Since BMD is not a reliable parameter for fracture risk prediction in MM subjects, it is necessary to use advanced tools such as FE analysis to predict individual fracture risk. If peaks are observed between adjacent segments in an MM patient, it can be safe to conclude that the spine is experiencing regions of structural instability. Such an FE visualization may have therapeutic consequences to prevent MM associated vertebral fractures.

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“…Medications for these morbidities (e.g. selective serotonin reuptake inhibitors, proton pump inhibitors, thiazolidinediones, aromatase inhibitors) thought to be associated with secondary osteoporosis [2] as well. The majority of osteoporosis medications are antiresorptive agents, which reduce the rate of bone remodeling and the bone resorption.…”

Section: Introductionmentioning

confidence: 99%

Co-Presence of Bisphosphonate-Related Osteonecrosis of the Jaw and Oral Squamous Cell Carcinoma in a Patient with Postmenopausal Osteoporosis: A Role for Chronic Traumatism?

Campisi¹

2017

EMIJ

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Introduction: Postmenopausal osteoporosis is an important global issue. The treatment generally includes the administration of antiresorptive agents, bisphosphonate (BP) or denosumab. The most reported adverse reaction to BP is the Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ). We report a case of BRONJ in an osteoporotic patient, who simultaneously revealed an oral squamous cell carcinoma (OSCC).Case report: A 84-year-old Caucasian female referred to our Department complaining of acute pain of one month's duration on the gingival, to the right side of the mandible. The patient had a history of post-menopausal osteoporosis treated with per osalendronate for 15 years. Clinical examination surprisingly also revealed the suspect of the contemporary presence of OSCC, that was confirmed by radiological features and histopathology. Conclusion:Unlike BRONJ or gastrointestinal damage associate to oral BP, oral ulcerations related to BP are not widely known. There is no clear evidence supporting the role of BP in the development of OSCC, but some cases of OSCC in patients taking BP are reported in literature. It would be prudent to screen and monitor these patients for all adverse reactions that could interest the oral cavity.

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MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

Cited by 267 publications

References 266 publications

Descriptive study of mandibular canal visibility: morphometric and densitometric analysis for digital panoramic radiographs

Descriptive study of mandibular canal visibility: morphometric and densitometric analysis for digital panoramic radiographs

Risk of vertebral compression fractures in multiple myeloma patients

Co-Presence of Bisphosphonate-Related Osteonecrosis of the Jaw and Oral Squamous Cell Carcinoma in a Patient with Postmenopausal Osteoporosis: A Role for Chronic Traumatism?

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