Management of Fatigue in Persons with Multiple Sclerosis

Khan, Farees; Amatya, Bhasker; Galea, Mary P.

doi:10.3389/fneur.2014.00177

Cited by 118 publications

(106 citation statements)

References 61 publications

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“…For example, in 2 studies, meaningful improvements in fatigue assessed with the FSS were seen shortly after introduction of ERT in some patients with Pompe disease [36,37]. Moreover, successful treatment of fatigue has been an important outcome in numerous chronic illnesses, including cancer, systemic lupus erythematosus, and multiple sclerosis [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Rethinking fatigue in Gaucher disease

Zion

Pappadopulos

Wajnrajch

et al. 2014

Molecular Genetics and Metabolism

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Section: Discussionmentioning

confidence: 99%

Rethinking fatigue in Gaucher disease

Zion

Pappadopulos

Wajnrajch

et al. 2014

Molecular Genetics and Metabolism

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“…MS'li bireylerin yaşadığı tüm semptomların, özellikle de yorgunluk semptomunun bireylerin günlük yaşam aktivitelerini etkilediği farklı çalışmalarda vurgulanmaktadır (8,11,13,14).…”

Section: Multiple Sklerozda Yorgunluk Ve Isı Duyarlılığıunclassified

A Different Approach to Fatigue Management in Multiple Sclerosis: Cooling Suit Application

Tuncay¹

2018

Deu Med J

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Nörolojik sistemi ilgilendiren kronik hastalıkların birçoğu, bireylerde ciddi şekilde sınırlılık ve yetersizlik yaşatan hastalıklar olarak kabul edilmektedir. Bu hastalıklar arasında yaygın olarak görülen Multiple Skleroz (MS); orta yaş ve genç yetişkinlerde sık yaşanan, neden olduğu fiziksel ve sosyal etkileri ile yaşam kalitesini etkileyen, kronik bir sağlık sorunudur (1-5). MS'de beyin, spinal kord ve optik sinirleri içeren sempatik sinir Ö Z Yorgunluk, multiple sklerozlu bireylerde en sık rastlanan semptomlardan biridir. Multiple skleroz ile ilişkili yorgunluğun değerlendirildiği çalışmalarda; çoğu yorgunluk vakasının çevresel ve vücut içi sıcaklığının yükselmesi ile arttığı belirlenmiştir. Multiple sklerozlu bireylerde vücut sıcaklığı düşürülerek sinir iletisinin hızlandırılması ve semptomların giderilmesi amacıyla çeşitli soğutma tedavisi yöntemleri kullanılmakta ve yorgunluk düzeyinde azalmalar olduğu bildirilmektedir. MS hastalarında soğutma tedavisi; soğuk su içme, soğuk duş alma, deriye soğuk ped uygulama veya soğutucu giysi gibi yapay soğutma sistemlerinin kullanımı ile sağlanmaktadır. Bu derleme, MS hastalarında yorgunluk yönetiminde soğutucu giysi uygulaması ile ilgili literatür bilgisini paylaşmak amacıyla yazılmıştır. Anahtar Kelimeler: Multipl Skleroz, Yorgunluk, Soğutucu Giysi ABSTRACT Fatigue is one of the most common symptoms in individuals with multiple sclerosis. In the studies evaluating the fatigue associated with multiple sclerosis, it was determined that fatigue increased with the elevation of body and environmental temperature in most of the cases. Various cooling methods are being used to accelerate nerve conduction and eliminate symptoms by reducing body temperature in the individuals with multiple sclerosis and it is reported that level of fatigue decreased with cooling therapies. In MS patients cooling treatment is provided by use of artificial cooling systems, such as drinking cold water, taking a cold shower, applying cold pad or cooling suits. This review aims to share knowledge about the application of cooling clothing in fatigue management in MS patients.

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“…Primary fatigue, for which the underlying pathophysiology is still unknown, is very common and can affect up to 95% of patients. 41,42 For many patients, fatigue represents the most severe MS-related symptom 43 that can occur at all stages of the disease. 44 Indeed, it is often present already at onset 45 and may even be a red flag for the later development of MS. …”

Section: Ms Fatiguementioning

confidence: 99%

Evaluation of cognition and fatigue in multiple sclerosis: daily practice and future directions

Penner

2016

Acta Neurol Scand

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The so-called hidden symptoms or soft signs of multiple sclerosis comprise cognitive dysfunction, fatigue, depression and anxiety. From a patient's perspective, these symptoms are rated as exerting much more negative impact on quality of life and daily functioning than their physical symptoms. Despite this knowledge, the symptoms remain disregarded by many neurologists in clinical practice. This missing awareness can be attributed to several reasons. First, the underlying pathophysiological mechanisms determining occurrence and severity of the different symptoms are still unclear.Second, there is uncertainty in how to reliably assess them. It is undeniable that assessment can be difficult as the hidden symptoms seldom appear isolated but more often highly interact. Third, if standardized, fast and cost-effective assessment to quantify and monitor the evolution of the hidden symptoms would be feasible, the question still remains how to treat these aspects. The present article will give an overview on symptom background and assessment strategies for clinical practice. Fatigue, cognitive dysfunction, depression and anxiety occur among all disease courses in multiple sclerosis (MS) with prevalence rates between 35% and 95% and even in patients with a so-called benign form.1 Due to a strong coincidence and interaction, these symptoms exert a strong negative influence on quality of life (QoL) and vocational status.2 From a patient's perspective, being affected by fatigue and cognitive decline is far from being benign and soft. Concerning the assumption that these symptoms rather remain hidden depends on the eye of the beholder. If you pay enough attention, you will see them very clearly. The only remaining question is how to objectify, classify and quantify them (Fig. 1). | COGNITIVE IMPAIRMENTCognition represents a central human ability, which refers to a wide range of higher order brain functions such as processing speed, memory, attention, executive functions and learning abilities. In MS, several cognitive domains can be affected, and once started, this impairment is often persistent and progressive. It is of importance to notice that cognitive problems can occur at early stages of the disease, 3 even in patients with clinically isolated syndrome 4 or radiologically isolated syndrome 5 and in paediatric MS as well 6 .The cognitive core deficits in adult MS are verbal and visual shortterm memory and learning, cognitive flexibility/attention and processing speed/fluidity. 7 As these three cognitive domains are highly relevant for daily functioning, patients experience a significant burden and diminished QoL due to reduced self-esteem, loss of social activities and contacts, and reduction or even loss of work responsibilities. 8Although progression of cognitive decline is generally slow, and in this sense different from other neurodegenerative diseases, the most vulnerable phase for progression seems to occur during the first 5 years after disease onset. This indicates that treatment aimed at protecting against cogni...

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Management of Fatigue in Persons with Multiple Sclerosis

Cited by 118 publications

References 61 publications

Rethinking fatigue in Gaucher disease

Rethinking fatigue in Gaucher disease

A Different Approach to Fatigue Management in Multiple Sclerosis: Cooling Suit Application

Evaluation of cognition and fatigue in multiple sclerosis: daily practice and future directions

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