Management of Fatigue in Rheumatoid Arthritis

Pope, Janet

doi:10.1136/rmdopen-2019-001084

Cited by 79 publications

(74 citation statements)

References 79 publications

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“…Similarly, also Van Hoogmoed et al (2010), andRepping-Wuts et al (2007) reported that pain, disability, depression, and low self-efficacy were associated with greater fatigue, but inflammatory indices were not correlated with fatigue severity. The fatigue in RA patients may be only partially related to disease activity, which may have accounted for poor agreement with respect to a fatigue domain within a flare questionnaire in RA (Pope, 2020). We found no significant difference in pain intensity and morning stiffness duration between the two study groups.…”

Section: Discussioncontrasting

confidence: 56%

Does the Course of Disease Influence the Development of Fatigue in Rheumatoid Arthritis Patients?

Kadisa

Nora-Krūkle

Sokolovska

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Patients with rheumatoid arthritis (RA) typically have many permanently inflamed joints. The inflammation inside the body can lead to general physical weakness, exhaustion, and drowsiness. This feeling of extreme tiredness is also called “fatigue”. Some people find this to be the worst symptom of the disease. However, the clinical significance of fatigue and its pathogenesis have not been recognised. This study aimed to determine the development of fatigue depending on activity and aggressiveness of RA. To achieve the goal, patients were interviewed and indicators of disease activity and aggressiveness were determined: rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (anti-CCP), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), immunoglobulins IgA RF, IgM RF, IgG RF and anti-carbamylated protein antibodies (anti-CarP). Based on the results of the survey, RA patients were divided into two groups — with and without fatigue. In the group of RA patients with fatigue, statistically more often an increase in IgA RF, IgM RF, and IgG RF levels was observed in those with elevated RF level, higher IgM RF and IgG RF levels were associated with increase in IgA RF level, and increase in the IgG RF and anti-CarP levels with elevation in the IgM RF level. A higher IgG RF level contributed to a higher anti-CarP level increase. Significant differences in the levels of clinical and laboratory inflammatory markers were not observed between the RA patients with and without fatigue. The obtained data suggest that the aggressive course of RA, more than inflammation, may contribute to the development of fatigue in RA patients.

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Section: Discussioncontrasting

confidence: 56%

Does the Course of Disease Influence the Development of Fatigue in Rheumatoid Arthritis Patients?

Kadisa

Nora-Krūkle

Sokolovska

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…Its pathophysiology is linked to disease activity, persistent pain, sleep deprivation, mood disturbances, other diseases, high inflammatory markers, elevated cytokines, with these a person feel tired or even exhausted similarly to prodrome of an infection. 19 Fatigue has been linked to conventional DMARDs use, specially methotrexate and sulfasalazine, this may contribute to non-adherence to their use, so change in mode of administration and dosing regimen may help. 20,21 Fatigue has severe financial impact leading to very high clinical care costs, increasing consultations, key determinant of sickness, absence and loss of employment, despite of its perceived importance and increased research activity, our understanding for prognostic factors of poor fatigue outcomes is lacking, ultimately poorly managed.…”

Section: Discussionmentioning

confidence: 99%

“…22 Curbing fatigue is possible, by multidimensional approach (non-pharmacologic and pharmacologic) measures, like exercise, cognitive behavioral therapy ,timely and effective use of conventional and biological dmards especially IL-6 blocker (Tocizilumab) and newer medications called conventional synthetic dmards Janus kinase (JAK) inhibitors (tofacinitab, baricinitab),in active, early RA, methotrexate naive, methotrexate and biologics inadequate responders shown major improvements, also treatment of anemia, Vit D and Omega 3 fatty acids supplementation may help. 19…”

Section: Discussionmentioning

confidence: 99%

Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study

Wagan¹,

Raheem²,

Bhatti³

et al. 2021

Pak J Med Sci

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Objective: To fine out fatigue frequency and severity by FACIT-F scale in Pakistani cohort with rheumatoid arthritis. Methods: This study was conducted at department of Medicine division of rheumatology CPMC Lahore. After the approval of IRB, 192 patients of RA were recruited. Written, informed consent was taken, demographic details were noted, patients filled the URDU version of FACIT-F (fatigue severity scale). 5-ml of blood was taken for fasting blood sugar, viral markers and ESR by a trained phlebotomist. Each individual’s disease activity was assessed by DAS-28 and FACIT-F score was calculated. Results: The Mean age (39.9±10.5) years, (71.9%) were females. Fatigue frequency was 62% (n=126), age, education, hypertension, DAS-28, exercise levels and HCV gives significant association with fatigue score. Linear regression analysis, results showed one unit increase in DAS-28 will gives 2.71 unit increases in fatigue scores(P <0.05). Conclusions: We have very high frequency of fatigue in RA, increases with disease activity & associated conditions. doi: https://doi.org/10.12669/pjms.37.4.3602 How to cite this:Wagan AA, Raheem A, Bhatti A, Zafar T. Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3602 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…The 23 survey questions were distributed over 14 webpages and divided into 4 domains: socio-demographic and work setting-related characteristics (12), referral to nonpharmacological care (2), treatment (5), and perceived quality of communication (4). The survey included both open-ended questions, asking the participants to answer in their own words, and closed questions, providing multiplechoice and multiple-response questions.…”

Section: Surveymentioning

confidence: 99%

“…In addition, care by health professionals is also based on treatments proven to be effective in other rheumatic diseases. For instance, promising approaches to address fatigue in patients with RA and SLE are also applicable for patients with SSc [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Opening the black box of non-pharmacological care in systemic sclerosis: a cross-sectional online survey of Dutch health professionals

et al. 2020

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The objective is to describe the spectrum of the health professional (HP) treatment approach for systemic sclerosis (SSc) from the perspective of Dutch HPs, including alignment of treatment goals set by HPs with self-reported referral reasons, coverage of patient-reported unmet care needs, and quality of communication between HPs and rheumatologists. Dutch HPs were invited through their patients with SSc to complete an anonymous online survey. The survey covered referral reasons, treatment goals, and interventions of the last patient treated, as well as the perceived quality of communication between HPs and rheumatologists. Referral reasons and treatment targets were linked to the International Classification of Functioning, Disability and Health following the refined ICF Linking Rules. Seventy-nine HPs from 8 professions (including 58 physiotherapists, 73%) completed the survey. One hundred and thirty-three different referral reasons were reported, yielding 58 different ICF codes, with 41 (70.7%) being linked to the ICF domain “body structures and functions.” The reported interventions focused on body functions/structures (27.9%), training of daily activities (25.6%), education and advice (26.3%), and psychosocial interventions (20.2%). The quality of communication between HPs and rheumatologists was perceived as low. Our findings revealed numerous treatment options offered by Dutch HPs addressing the unmet care needs of patients with SSc. There is an overlap in the content of the various HP disciplines, and HP treatment goals are not sufficiently aligned with referrals of rheumatologists. HP treatment offer seemed inefficiently organized, possibly precluding rheumatologists from making targeted referrals. Communication between rheumatologists and HPs should be improved.

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Management of Fatigue in Rheumatoid Arthritis

Cited by 79 publications

References 79 publications

Does the Course of Disease Influence the Development of Fatigue in Rheumatoid Arthritis Patients?

Does the Course of Disease Influence the Development of Fatigue in Rheumatoid Arthritis Patients?

Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study

Opening the black box of non-pharmacological care in systemic sclerosis: a cross-sectional online survey of Dutch health professionals

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