Management of genital herpes simplex virus infection occurring during pregnancy

Boehm, Frank H.; Estes, Wray; Wright, Peter F.; Growdon, James F.

doi:10.1016/0002-9378(81)90697-9

Cited by 25 publications

(5 citation statements)

References 6 publications

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“…Several authors have recently suggested that time limitations should not be applied to these patients when deciding on cesarean section since it is impossible to weigh the various factors that determine whether viral transmission has occurred. 5 ' 18 Available data are not sufficient to fully assess the possible reduction in neonatal herpes from this approach. It is clear that ascending infection can be easily established 6 hours after rupture of membranes, and there are a number of cases where cesarean section did not prevent fetal infection when membrane rupture occurred more than 6 hours before.…”

Section: 'mentioning

confidence: 99%

Maternal Herpes Infection Complicated by Prolonged Premature Rupture of Membranes

Ray¹,

Evans²,

Elliott³

et al. 1985

Amer J Perinatol

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Three cases of patients who developed genital herpes virus infections after prolonged, premature rupture of membranes (PROM) at 28-31 weeks gestation are reported. These patients were expectantly managed without immediate intervention at the time of diagnosis of the genital herpes virus infection. In all three cases, there was no evidence of neonatal herpes virus infection at the time of delivery or before hospital discharge. The spectrum of decisions facing the physician managing a patient with prolonged PROM and a genital herpes virus infection is discussed, and a rational approach to management presented.

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Section: 'mentioning

confidence: 99%

Maternal Herpes Infection Complicated by Prolonged Premature Rupture of Membranes

Ray¹,

Evans²,

Elliott³

et al. 1985

Amer J Perinatol

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“…15 Knowledge of the potential hazards of HSV infection for newborn infants has increased the use of cesarean section for women who have or are suspected of having genital herpes near or at the time of delivery. 16 HSV can be identified using several laboratory methods, including viral culture, direct examination of the specimen, immunology, immunohistochemistry and PCR. Direct examination can be performed on Papanicolaou-stained cytologic specimens or by the Tzanck test to demonstrate classic cytologic changes in the specimen.…”

Section: Discussionmentioning

confidence: 99%

Rapid Detection of HSV from Cytologic Specimens Collected into ThinPrep Fixative

Fiel-Gan

Villamil²,

Mandavilli³

et al. 1999

Acta Cytologica

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“…Cesarean section is indicated in mothers with virologically active lesions and intact (or ruptured less than 6 h) membranes, but vaginal delivery may be used if careful virologic surveillance indicates the maternal birth canal is free of virus. 58 Herpes simplex viruses are spread by direct contact and are excreted in liberal quantities from skin lesions and, occasionally, from the upper respiratory tract. These viruses are extremely dangerous to newborn contacts.…”

Section: Congenital and Perinatal Herpes Simplex Infectionsmentioning

confidence: 99%

Infections of the Newborn

Marks

1985

Pediatric Infectious Diseases for the Practitioner

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Infections of the Newborn General ConsiderationsNewborns are special! They are exposed to several diverse environments during their intrauterine, perinatal, and postnatal lives. Because of this, and their relatively immature state of physical and immunological development, they have infectious disease problems that deserve special emphasis. In fact, there are textbooks exclusively devoted to infectious diseases of the fetus and newborn. Do not worry, this chapter will not attempt to be comprehensive in every detail, but rather focus on the commonest problems. Newborn Environments (Fig 3-1)The first world the fetus encounters is unique in several aspects.Intrauterine. The ideal isolation room-or is it? There is no problem with airborne infection and direct contact with infected persons is. impossible. Maternal immunity is altered so that tolerance is pronounced, allowing the fetus to persist without immunologic challenge, in most cases. Contact between the mother's environment and the fetus is maintained and controlled via the placenta and umbilical cord, which are generally effective in limiting in utero antigenic exposure of the fetus. Nevertheless, breakthroughs occur. A common example is congenital cytomegalovirus infection, probably the most frequent congenital infection. Other maternal infections in the first trimester (e.g. influenza, measles, tuberculosis, etc.) have been associated with abortion and fetal death. These severe outcomes may be nature's way of avoiding horrendous congenital anomalies. In fact, these infections can be likened to lethal mutations, since they occur so early in embryonic development.

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Management of genital herpes simplex virus infection occurring during pregnancy

Cited by 25 publications

References 6 publications

Maternal Herpes Infection Complicated by Prolonged Premature Rupture of Membranes

Maternal Herpes Infection Complicated by Prolonged Premature Rupture of Membranes

Rapid Detection of HSV from Cytologic Specimens Collected into ThinPrep Fixative

Infections of the Newborn

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