Management of gestational trophoblastic neoplasia

Hussain, Ansar; Aziz, Shiekh Aejaz; Mohd, Gul; Bhat,; Ar, Lone

doi:10.15761/cogrm.1000103

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Methotrexate-based Therapy Of Gestational Trophoblastic Disease1

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2020

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References 38 publications

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“…The work of Agarval et al concerns the validation of the uterine artery pulsatility index (UAPI, a measure of tumour vascularity) as a useful indicator for predicting resistance to MTX chemotherapy [288]. A similar issue is also the subject of the works of Secki et al [289] and Hussain et al [290]. Stratification of patients of lowor high-risk GTN for single-agent chemotherapy (with MTX-LV or ACT) or multi-agents chemotherapy, respectively, is based on the assessment of the CXH and FIGO indexes.…”

Section: Methotrexate-based Therapy Of Gestational Trophoblastic Diseasementioning

confidence: 99%

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Koźmiński

Halik

Chesori

et al. 2020

IJMS

225

120

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Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer’s disease or myasthenia gravis will be discussed.

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Section: Methotrexate-based Therapy Of Gestational Trophoblastic Diseasementioning

confidence: 99%