Management of giant anal condyloma by wide local excision and anoplasty

Uribe, Natalia; Rueda, Cristina Álvarez-Palencia; López, Manuel; Balciscueta, Zutoia; Martín, M. Carmen; Jj, Terradez Raro; Flores, Juan

doi:10.1111/j.1463-1318.2012.03006.x

Cited by 8 publications

(9 citation statements)

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“…A review of the literature shows only case reports or small case series, 5,12,13 and one of the largest series, covering the period from 1999 to 2011, reported 9 consecutive patients (6 PLHIV) with GPC (the sizes of the GPCs were not reported) treated by wide local excision and anoplasty. 5 We herein report 14 cases (9 PLHIV) of GPC treated topically between 2015 and 2019. All the perianal lesions were circumferential, measuring between 8 cm and 20 cm, and significantly decreased in size over the course of the treatment.…”

Section: Discussionmentioning

confidence: 99%

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Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum

López

Rosa

Cipollone

et al. 2021

Journal of Coloproctology

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Purpose Giant perianal condyloma (GPC) is a rare condition. The effective treatment is a multidisciplinary challenge; topical treatments are usually ineffective, and surgical resection has significant morbidity. Podophyllin at 25% in solid petrolatum (25%PSP) can be an effective treatment option for GPC. The aim of the present study was to assess its response and tolerability. Methods This retrospective, single-center case series evaluated the clinical response of 14 patients with GPC treated with 25%PSP in a public hospital in Buenos Aires between December 2015 and December 2019. After obtaining a full history and performing a physical exam, the lesions were measured and photographed. Biopsies were performed to exclude malignancy, as well as exams to rule out pregnancy. Podophyllin at 25% in solid petrolatum was administered topically in cases of GPC and washed off by the patients at home after 4 hours. The patients underwent at least 4 weekly visits, which included interval history, photodocumentation of the lesions, and provider-applied 25%PSP. The response rate was assessed by comparing measurements and the overall decrease in volume of the GPC based on photos from the first and last sessions. Adverse outcomes were noted. Results In total, 10 men, 3 women, and 1 transgender woman with GPC unresponsive to prior treatments and a mean age of 34.5 years were included. A total of 12 patients were immunosuppressed. All the perianal lesions were circumferential and measured between 8 cm and 20 cm. Overall, 7 patients had genital condyloma outside of the anus and perianus; the histology showed low-grade squamous intraepithelial lesions in all cases. While on treatment, 7 patients reported dermatitis, and 71% of the patients had ≥ 75% reduction in lesion size. Conclusions Podophyllin at 25% in solid petrolatum is an effective, well-tolerated topical treatment option for GPC.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Surgical excision of GPC is associated with risks of chronic pain, wound infection, incontinence, or anal stenosis, which could interfere with quality of life. 4,5 Because of the potential perioperative and postoperative morbidities, effective non-surgical options would be very helpful.…”

Section: Introductionmentioning

confidence: 99%

Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum

López

Rosa

Cipollone

et al. 2021

Journal of Coloproctology

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show abstract

“…The site of hand-device placement varies with the surgeon. Some prefer placing it in the right iliac fossa or suprapubic region [2,3], while others prefer a lower midline incision [4], as in the report of Ng et al What makes laparoscopic right colectomy a technically challenging procedure is that it requires the use of different abdominal quadrants, ligation of large vessels and division of the mesentery. It has been demonstrated that the distance from the base of the palm to…”

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confidence: 99%

“…Reply to Vergara-Fernández et al doi:10.1111/codi.12194 Dear Sir, I thank Vergara-Fernández et al [1] for their interest in our recent article, 'Management of giant anal condyloma by wide local excision and anoplasty' [2]. In relation to the questions, these are answered in the text.…”

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confidence: 99%

**Comment on Mallappa et al.: Preoperative neutrophil to lymphocyte ratio >5 is a prognostic factor for recurrent colorectal cancer**

et al. 2013

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“…I thank Vergara‐Fernández et al . for their interest in our recent article, ‘Management of giant anal condyloma by wide local excision and anoplasty’ . In relation to the questions, these are answered in the text.…”

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confidence: 99%

Reply to Vergara‐Fernández et al

Uribe

2013

Colorectal Disease

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Management of giant anal condyloma by wide local excision and anoplasty

Abstract: Extensive local surgery of giant perianal condyloma with anoplastic reconstruction gives good results even in HIV-positive patients.

Cited by 8 publications

References 19 publications

Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum

Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum

**Comment on Mallappa et al.: Preoperative neutrophil to lymphocyte ratio >5 is a prognostic factor for recurrent colorectal cancer**

Reply to Vergara‐Fernández et al

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