Background: Despite advances in the medical management of peptic ulcer disease, duodenal ulcer (DU)
perforation remains a common surgical emergency. Most DU perforations are small and can be managed
with omental patch repair. However, occasionally the surgeon may encounter a giant perforation not
amenable to this. Giant DU perforations are defined as > 2cm. They are associated with high leak rates and
mortality. Prognosis in elderly patients are particularly poor because of advanced age and comorbidities.
Furthermore, there are no specific recommendations for their management despite a variety of repair
techniques being described. Here, we aim to describe a novel technique used to treat such patients, especially
those of advanced age, in our institution and to review the current literature.
Case presentation: Four patients with giant DU perforation underwent emergency laparotomy and repair
with our duodenojejunostomy technique at our hospital. Post-operatively, patients were monitored clinically
and radiologically and discharged when well and tolerating diet. The mean age of the patients was 67 years
with an equal gender distribution. The average Charlson Comorbidity Index (CCI) score was 3 (moderately
severe). All presented with peritonitis and two had concomitant bleeding. There were two anterior and two
posterior ulcers. One was a revision repair after a leak post laparoscopic omental patch repair for the initial
perforation. In all cases, the duodenojejunostomy repair technique was used. Post-operative recovery was
uneventful for all except one who developed pneumonia. In particular; there were no anastomotic leaks,
intra-abdominal collections, gastric outlet obstructions or mortalities.
Conclusion: Giant DU perforation remains a challenge to the general surgeon, particularly so in elderly
patients with multiple comorbids. A review of the current literature suggests a myriad of surgical techniques
but no perfect solution. Some suggested techniques include omental patch with pyloric exclusion, controlled
tube duodenostomy, jejunal pedicled graft or serosal patch, gastric disconnection and partial gastrectomy.
Here, we propose that isolated duodenojejunostomy can be a quick, safe and novel solution that ensures
definitive repair of giant ulcer perforation in a single setting in the high-risk patient.