Management of haemostatic complications of chimaeric antigen receptor T‐cell therapy

Swan, Dawn; Thachil, Jecko

doi:10.1111/bjh.18045

Br J Haematol

2022

DOI: 10.1111/bjh.18045

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Management of haemostatic complications of chimaeric antigen receptor T‐cell therapy

Dawn Swan

Jecko Thachil²

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2024

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Cited by 1 publication

References 97 publications

(231 reference statements)

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CAR-T cell therapy in Multiple Myeloma: current status and future challenges

Swan,

Madduri,

Hocking

2024

Blood Cancer J.

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The treatment of multiple myeloma has changed dramatically in recent years, with huge strides forward made in the field. Chimeric antigen receptor T-cell therapy targeting the B cell maturation antigen (BCMA) is now widely approved in relapsed refractory patients and is moving into earlier treatment lines. In this review, we discuss the evidence underpinning current regulatory approvals and consider mechanisms through which CAR-T cell efficacy could be improved. These include tackling BCMA-loss, harnessing the immunosuppressive tumour microenvironment, manufacturing concerns including the potential role of other cellular sources, safety issues such as cytokine release syndrome and neurotoxicity, and optimal patient selection.

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CAR-T cell therapy in Multiple Myeloma: current status and future challenges

Swan,

Madduri,

Hocking

2024

Blood Cancer J.

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Management of haemostatic complications of chimaeric antigen receptor T‐cell therapy

Cited by 1 publication

References 97 publications

CAR-T cell therapy in Multiple Myeloma: current status and future challenges

CAR-T cell therapy in Multiple Myeloma: current status and future challenges

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