Management of Helicobacter pylori Infection: What Should the Surgeon Know

Abstract

Infection with Helicobacter pylori continues to represent a major global health care burden, and various national and international consensus reports and guidelines have aimed at tracking recent developments for their translation into an optimized clinical management. The most important ‘innovation' is the definition of H. pylori gastritis as an infectious disease. This does imply the consideration of therapy of this condition even before the development of clinical manifestations including non-malignant and malignant gastroduodenal diseases, such as peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. Treatment of H. pylori is facing an increasing number of failures, with the main reason being an increasing antibiotic resistance to some of the previously most effective antibiotics, i.e. clarithromycin and levofloxacin, for H. pylori strains. Several new treatment options or modifications of already established regimens have been introduced to overcome bacterial resistance and treatment failure. In this review, we provide an update on the current recommendations for a successful management of H. pylori infection, and in this context a special reference is made to the role of visceral surgeons.

Comparing Diagnostic Performance of Pronto Dry Rapid Urease® and Culture to Histopathology among Endoscopy Patients at the Aga Khan University Hospital, Nairobi-Kenya

“…This study found out that Pronto dry rapid urease® out performed culture in sensitivity and NPV measures. This findings are in agreement with similar studies performed in elsewhere [12,13,14] Moreover, sensitivity of Pronto dry rapid urease® according to the manufacturer is similar with our findings [15]. The observed high sensitivity makes Pronto dry rapid urease® appropriate for screening ahead of the more time consuming confirmatory tests.…”

“…It is possible some participants may have taken antibiotics and could not tell they were those in question. This culture findings are however not unique to this study, since even a study conducted by [18] had similar results. Culture is imperative for antimicrobial susceptibility profiling.…”

The Effect of Quadruple Therapy Plus Probiotics on Helicobacter Pylori Eradication and Antibiotic-Associated Side Effects: A Randomized Placebo-Controlled Trial

“…Helicobacter pylori (H. pylori) is a gram-negative, flagellated, microaerophilic bacterium that colonizes the human gastric mucosa (1) and causes chronic gastritis, peptic ulcer, and gastric cancer, as well as mucosa-associated lymphoid tissue (MALT) lymphoma. Recent studies have reported that H. pylori infection is an independent risk factor associated with unexplained iron-deficiency anemia and micronutrient deficiency (iron and vitamin B12) (2,3).…”

Prevalence and Endoscopic Findings of <i>Helicobacter pylori</i> Infection among Dyspeptic Patients in Kenya

“…Neither of these diagnostic tools is considered to be the gold standard due to poor sensitivity or specificity. The choice of diagnostic test depends on the prevalence, age-related gastric cancer incidence in each area, accessibility, advantages and disadvantages of each method as well as different clinical circumstances of each patient [8] Aim of the study was to investigate association of Helicobacter pylori infection with endoscopic findings amongst dyspeptic patients at Aga Khan University Hospital.…”