Management of hepatic metastasis of gastrointestinal carcinoid tumors

Landry, Christine S.; Scoggins, Charles R.; McMasters, Kelly M.; Martin, Robert C.G.

doi:10.1002/jso.20957

Cited by 69 publications

(59 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As no neuroendocrine cells have ever been detected in the kidneys, 11 several theories have been proposed as to the exact pathogenesis of renal carcinoid tumours, including urothelial metaplasia, 12 metastases from undiscovered primaries, entrapped neural crest or pancreatic cells and primitive stem cell differentiation. 1,10 Although our patient did not have any anatomical urological abnormalities, the high associations of renal carcinoid with horseshoe kidneys (17.8%) and teratomas (14.3%) suggest that the development of these tumours is related to predisposing embryological factors.…”

Section: Case Reportmentioning

confidence: 99%

“…11 There is good evidence for survival after excision of involved lymph nodes and resection of metastatic hepatic metastases, but not for debulking of unresectable primary or secondary tumours. 12 The choice of chemotherapeutic agents remains controversial even for the more common gastrointestinal and respiratory carcinoid tumours. Response rates are low, with combination regimens of streptozocin and fluorouracil (33%) or streptazoin and cyclophosphamide (26%), as well as single agents such as fluorouracil, streptozocin, or doxorubicin (20%).…”

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Primary renal carcinoid tumour with inferior vena caval tumour thrombus

Szymański

Baazeem

Sircar

et al. 2013

CUAJ

View full text Add to dashboard Cite

Carcinoid tumours, most frequently reported in the gastrointestinal and respiratory tracts, are exceedingly rare primary renal cancers. Few cases have been published to date. To our knowledge, we report the first case of a primary carcinoid tumour of the kidneys involving the inferior vena cava. We treated a 58-year-old woman with an open radical nephrectomy and cavotomy with thrombectomy. We describe the presentation, investigations and pathology results. We discuss the current experience with carcinoid tumours as a literature review relating to the diagnosis of the disease and the prognosis of patients with this neoplasm. Localized carcinoid tumours of the kidneys, including those involving the vena cava, can be successfully treated with surgical excision. RésuméLes carcinoïdes, principalement observés dans le tractus digestif et les voies respiratoires, sont des tumeurs rénales primitives extrêmement rares. Quelques cas seulement ont été publiés jusqu'à présent. Nous décrivons le premier cas de carcinoïde primitif du rein touchant la veine cave inférieure. Nous avons traité la patiente, âgée de 58 ans, par néphrectomie radicale ouverte et thrombectomie par cavotomie. Nous présentons ici les détails du cas au moment de la consultation, les examens effectués et les résultats des analyses de pathologie. Le niveau actuel d'expéri-ence avec ce type de tumeur est discuté sous forme de revue de la littérature en lien avec le diagnostic et le pronostic. Les carcinoïdes localisés du rein, y compris ceux touchant la veine cave, peuvent être traités avec succès par excision chirurgicale.

show abstract

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Primary renal carcinoid tumour with inferior vena caval tumour thrombus

Szymański

Baazeem

Sircar

et al. 2013

CUAJ

View full text Add to dashboard Cite

show abstract

“…Similarly, drug-eluting beads with doxorubicin (DEBDOX) has also been found to be safe and effective in the management of metastatic NETs to the liver [7].…”

Section: Introductionmentioning

confidence: 99%

Transarterial Chemoembolization and Selective Internal Radiation for the Treatment of Patients with Metastatic Neuroendocrine Tumors: A Comparison of Efficacy and Cost

et al. 2011

View full text Add to dashboard Cite

Background. Hepatic arterial therapy (HAT) has been proven to be effective at palliation of hormonal symptoms of metastatic neuroendocrine tumors (NETs), as well as a means of cytoreduction. Recently, the newer modalities of yttrium-90 and drug-eluting beads with doxorubicin (DEBDOX) have been reported to be effective in the treatment of metastatic NETs. The aim of this study was to compare the safety, efficacy, and cost of selective internal radiation with DEB therapy.Methods. An institutional review board-approved, multicenter, multinational prospective treatment registry to investigate the safety and efficacy of yttrium-90 and doxorubicin microspheres was reviewed.Results. In all, 43 patients underwent a combined 69 HAT treatments, with 15 patients receiving 23 yttrium-90 treatments and 28 patients receiving 46 DEB-

show abstract

“…Concerning other prognostic parameters for primary NETs and liver metastases, Katz et al demonstrated that the robust presence of tumor-infiltrating lymphocytes is a significant predictor of outcome [44]. Other recent articles confirmed surgical therapy to be the most efficient approach against solitary hepatic metastases [7,8,14,22,23,33,34,40,45,46], with a potential curative resection of liver secondaries can be undertaken in 13.7 to 24.5% of patients with metastatic NETs [47][48][49], and a significant reduction of carcinoid symptoms [43], but the majority of studies focused exclusively on resection rather than combined-modality approaches with ablation or chemotherapy.…”

Section: Liver Metastases From Neuroendocrine Tumorsmentioning

confidence: 99%

“…In fact, metastases are well recognized as being the major cause of death among neoplastic patients, and the prognosis of patients affected by unresectable liver metastases is very poor. However, although once metastatic malignancies were commonly considered as a terminal neoplastic stage, nowadays, many different therapeutical options have been introduced in order to provide a safe and efficient treatment for these kinds of patients and improve both their quantity and quality of life [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Surgical Indications, Timing, and Strategy in Non-colorectal Liver Metastases

Uzzau¹,

Bertozzi²,

Londero³

et al. 2015

Recent Advances in Liver Diseases and Surgery

View full text Add to dashboard Cite

Taking into consideration all primary solid tumors, the liver represents the most common site involved in distant metastasization, also due to its important blood reception from the majority of digestive organs. Despite the abundant literature and guidelines about colorectal liver metastases, there is still great debate about the treatment strategy in the case of non-colorectal ones. Therefore, in this chapter, we reviewed the treatment strategy and surgical indications for the most frequent non-colorectal liver metastases. In the case of neuroendocrine hepatic secondaries, the literature suggests that surgery should be always considered for patients with resectable hepatic disease, as this treatment results more likely to offer the best long-term outcome. For what concerns liver metastases from gastric cancer, surgical approach should always be undertaken if indications are appropriate, after a multidisciplinary discussion to plan an adequate multidisciplinary adjuvant treatment, a proper patient selection, and the exclusion of additional secondary tumors or extrahepatic metastases. Taking into consideration liver secondaries from breast cancer and their chemosensitivity, in the absence of brain and lung lesions, it can be considered a space for liver surgery, especially in the case of single lesions or a maximum of two lesions with dimensions within 3 cm. However, as the number of cancer survivors is progressively increasing and, with it, the number of patients affected by non-colorectal liver metastases, further randomized controlled trials are required in order to better define the benefit of hepatic surgery in these kinds of patients.

show abstract

Management of hepatic metastasis of gastrointestinal carcinoid tumors

Abstract: Multimodality therapy in the management of hepatic carcinoid metastasis can be done safely and effectively. We recommend the use of hepatic resection when feasible as this treatment most likely offers the best long-term outcome.

Cited by 69 publications

References 16 publications

Primary renal carcinoid tumour with inferior vena caval tumour thrombus

Primary renal carcinoid tumour with inferior vena caval tumour thrombus

Transarterial Chemoembolization and Selective Internal Radiation for the Treatment of Patients with Metastatic Neuroendocrine Tumors: A Comparison of Efficacy and Cost

Surgical Indications, Timing, and Strategy in Non-colorectal Liver Metastases

Contact Info

Product

Resources

About