Management of Hepatocellular Carcinoma: Bangladesh Perspective

Noor-E-Alam, Sheikh Mohammad

doi:10.5005/jp-journals-10018-1258

Cited by 10 publications

(13 citation statements)

References 123 publications

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“…Bangladesh is a densely populated country with a high prevalence of HBV infection and HBV-induced HCC [23]. HBV genotype C is the most prevalent subtype in the Indian subcontinent, including in Bangladesh [24][25][26], and is thought to be more harmful and more likely to lead to HCC [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh

Hossain

Mahmud

Nazir

et al. 2020

IJMS

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Mutations in the hepatitis B virus (HBV) genome can potentially lead to vaccination failure, diagnostic escape, and disease progression. However, there are no reports on viral gene expression and large hepatitis B surface antigen (HBsAg) antigenicity alterations due to mutations in HBV isolated from a Bangladeshi population. Here, we sequenced the full genome of the HBV isolated from a clinically infected patient in Bangladesh. The open reading frames (ORFs) (P, S, C, and X) of the isolated HBV strain were successfully amplified and cloned into a mammalian expression vector. The HBV isolate was identified as genotype C (sub-genotype C2), serotype adr, and evolutionarily related to strains isolated in Indonesia, Malaysia, and China. Clinically significant mutations, such as preS1 C2964A, reverse transcriptase domain I91L, and small HBsAg N3S, were identified. The viral P, S, C, and X genes were expressed in HEK-293T and HepG2 cells by transient transfection with a native subcellular distribution pattern analyzed by immunofluorescence assay. Western blotting of large HBsAg using preS1 antibody showed no staining, and preS1 ELISA showed a significant reduction in reactivity due to amino acid mutations. This mutated preS1 sequence has been identified in several Asian countries. To our knowledge, this is the first report investigating changes in large HBsAg antigenicity due to preS1 mutations.

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Section: Introductionmentioning

confidence: 99%

PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh

Hossain

Mahmud

Nazir

et al. 2020

IJMS

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“…Hepatitis was estimated as the 2 nd the prevalence of hepatitis in Pakistan was in 2 nd position among other diseases [10]. One of the study in Bangladesh showed that majority of cirrhosis patients were (68%) males and (31.82%) were females [2] and 50% of the patients were in the age group of 31 -50 years [11]. In Bangladesh HCC being the third most common cause of cancer deaths, it is just behind cancer of the stomach [12] [13].…”

Section: Introductionmentioning

confidence: 99%

Lived Experience with Cirrhosis of Liver Patient at a University Hospital: A Qualitative Study

Jannat¹,

Anowar²,

Islam³

et al. 2020

OJGas

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Introduction: Patients' physical, psychosocial, economical, spiritual and daily activities as well as quality of life are mostly affected by the cirrhosis of liver. It is an advanced stage of liver fibrosis that mostly caused by hepatitis B and hepatitis C, and alcoholism. Objective: This study is intended to explore the lived experience of the patient's with cirrhosis of liver patients. Methodology: A Phenomenological study design was used as a research methodology to elicit in-depth understanding of lived experience of the hospitalized adult cirrhosis of liver patients at

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“…Although HCC has been a major public health problem for several decades, the prognosis of HCC was devastating before three decades with most patients dying within the first year after diagnosis irrespective of management strategies. 3,4 Even, developed countries were not exception to this fundamental. However, some concurrent developments altered the scenario of HCC diagnosis and management tremendously during last-two to three decades.…”

Section: Introductionmentioning

confidence: 99%

“…6 Bangladesh is a country of about 170 million people with hepatitis B virus (HBV) carrier rate of 2-5% and hepatitis C virus (HCV) carrier rate of about 1%. 7 Although nation-wise epidemiological data are not available about prevalence of HCC in Bangladesh, there seems 1,3 to be several thousand patients with HCC in this country. However, a workable and standardized surveillance and management system of HCC is yet to be developed for Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

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Treatment by Transarterial Chemoembolization and Sorafenib for Hepatocellular Carcinoma vs Advanced Hepatocellular Carcinoma in Bangladesh: A Real-life Situation

et al. 2017

Euroasian Journal of Hepato-Gastroenterology

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Background: Although there are thousands of patients with hepatocellular carcinoma (HCC) in Bangladesh, almost there is no nationwide recommendations for therapeutic maneuver for HCC patients. As most of the HCC patients of Bangladesh are diagnosed late, patients with advanced HCC with large and multiple HCC nodules represent the usual presentation of HCC. The study is presented here to assess the effects of a combined therapy of transarterial chemoembolization (TACE) and sorafenib in advanced HCC patients. Materials and methods: A total of 77 patients with advanced HCC were enrolled in this study. All of them had advanced HCC with variable etiologies and clinical conditions. All patients were treated by TACE and also given systemic sorafenib at the same time. The patients were checked 1 and 3 months after therapy commencement. Results: Out of 77 patients, 18 patients died within 1 month and additional 15 patients died within 3 months after therapy commencement. Thus, there remains 44 surviving patients after 3 months. When different parameters of dead patients and survived patients were compared, no specific parameters dictated the factors about overall survival of more than 3 months. Discussion: This is the first approach to initiate an invasive and a systemic therapy for treatment of advanced HCC in Bangladesh. Further follow-up of patients and their long-term overall survival may cast some lights about the role of these therapies in Bangladeshi HCC patients.

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Management of Hepatocellular Carcinoma: Bangladesh Perspective

Cited by 10 publications

References 123 publications

PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh

PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh

Lived Experience with Cirrhosis of Liver Patient at a University Hospital: A Qualitative Study

Treatment by Transarterial Chemoembolization and Sorafenib for Hepatocellular Carcinoma vs Advanced Hepatocellular Carcinoma in Bangladesh: A Real-life Situation

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