Management of hypertension in elderly diabetic patients

Blicklé, J. F.

doi:10.1016/s1262-3636(05)73656-9

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…Several major trials of anti-hypertensive treatment in the elderly (>65 years old), conducted with thiazide diuretics (Th), calcium channel blockers (CCB) or angiotensin converting enzyme inhibitors (ACE-inhibitors), have shown that antihypertensive treatment reduces the risk of cardiovascular mortality, stroke and heart failure to a similar or even greater extent in older people than in younger people, and subgroup analyses have indicated that the absolute benefit is even greater in diabetic patients. A meta-analysis of the subgroups of patients >80 years old included in these studies (33) and HYVET study (34) confirmed the beneficial effects of treatment on stroke and heart failure (8).…”

Section: Blood Pressure Controlmentioning

confidence: 66%

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Key priorities in managing glucose control in older people with diabetes

Bourdel-Marchasson

Doucet

Bauduceau

et al. 2009

The Journal of nutrition, health and aging

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Older people with diabetes represent a major and increasing proportion of our elderly population and their care requires better organisation. Targets for risk factor control and pathways of care must be adjusted to the subject's general health status. It is thus advisable to screen for frailty. We have carried out a detailed literature review of the studies published on diabetes in older people since 1990. Studies were considered if they included groups or subgroups of diabetic patients > 65 years old. This review discusses the elaboration of general targets for care, the approach to risk factor control, the screening and the specific prevention or management of complications, the integration of geriatric concepts in diabetes care and the specificity of education with respect to frailty status.

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Section: Blood Pressure Controlmentioning

confidence: 66%

“…In the present report, we propose key priorities in diabetes management in the elderly, based on our literature review (1, 5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] combined with the geriatric concept of frailty assessment (10,23).…”

Section: Introductionmentioning

confidence: 99%

Key priorities in managing glucose control in older people with diabetes

Bourdel-Marchasson

Doucet

Bauduceau

et al. 2009

The Journal of nutrition, health and aging

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“…Pseudomonas aeruginosa accounts for a significant proportion of infections among catheter‐associated urinary tract infection in long‐term care facilities, diabetic foot infections and lung infections of cystic fibrosis and other immunocompromised patients (Stoodley et al. 2002; Blickle 2005; Obritsch et al. 2005; Nordmann et al.…”

Section: Introductionmentioning

confidence: 99%

A NEW FLUOROGENIC ASSAY FOR MONITORING AND DETERMINING PLANKTONIC AND BIOFILM FORMS OF PSEUDOMONAS AERUGINOSA VIABLE COUNT IN VITRO

Elkhatib

Noreddin²

2009

Rapid Methods Automation Mic

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A new method was developed to rapidly monitor the Pseudomonas aeruginosa viable counts using alamar blue (AB). The 96‐well microtiter plates were used to perform the assay. This procedure is based on fluorogenic measurement as a result of reduction of nonfluorescent AB to red fluorescent form by the viable cells of P. aeruginosa. The correlation between conventional plate count and fluorogenic AB method was highly satisfactory for quantification of planktonic (R2 = 0.9487) and biofilm cells of P. aeruginosa (R2 = 0.9296). PRACTICAL APPLICATIONS The new fluorogenic method can rapidly monitor Pseudomonas aeruginosa counts in vitro with a high correlation with the conventional plating method. The results indicate that fluorogenic method requires much shorter time (2 h) than the conventional plate count (24 h), is a more cost‐effective way, quite amenable to high throughput, and continuous monitoring of P. aeruginosa viability is achievable in the kinetic in vitro models without interference with the cell viability.

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“…Diltiazem is a potent vasodilator that is generally well-tolerated [1,2]. As such, it is a commonly used treatment for elderly patients including those who are diabetic [3].…”

Section: Introductionmentioning

confidence: 99%

“…Pseudomonas aeruginosa biofilms account for a significant proportion of infections among catheterassociated urinary tract infection (UTI) in long-term care facilities, diabetic foot infections and lung infections of cystic fibrosis and other immunocompromised patients [3][4][5][6][7]. The biofilm matrix affords the bacteria protection from antibiotic penetration leading to suboptimal treatment levels at the site of infection and potentially inducing outgrowth of resistant strains [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Unexpected induction of resistant Pseudomonas aeruginosa biofilm to fluoroquinolones by diltiazem: A new perspective of microbiological drug–drug interaction

Elkhatib

Haynes

Noreddin

2008

Journal of Infection and Public Health

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The increase of multi-drug resistant Pseudomonas aeruginosa infections is a worldwide dilemma. At the heart of the problem is the inability to treat established P. aeruginosa biofilms with standard antibiotic therapy, including fluoroquinolones. We address a previously unstudied question as to the effect of a commonly prescribed calcium channel blocker (CCB) diltiazem on the biofilm growth. Real-time monitoring of the overall growth and killing of P. aeruginosa biofilm during fluoroquinolones therapy in the presence and absence of diltiazem was performed. In this study, we demonstrate that for P. aeruginosa biofilms, resistance to the first-line fluoroquinolones may be induced by the commonly prescribed calcium channel blocker diltiazem.

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Management of hypertension in elderly diabetic patients

Cited by 10 publications

References 42 publications

Key priorities in managing glucose control in older people with diabetes

Key priorities in managing glucose control in older people with diabetes

A NEW FLUOROGENIC ASSAY FOR MONITORING AND DETERMINING PLANKTONIC AND BIOFILM FORMS OF PSEUDOMONAS AERUGINOSA VIABLE COUNT IN VITRO

Unexpected induction of resistant Pseudomonas aeruginosa biofilm to fluoroquinolones by diltiazem: A new perspective of microbiological drug–drug interaction

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