“…In the modern era of limb salvage surgery, primary sarcomas of bone are typically treated with wide resection followed by reconstruction with allograft bone, an endoprosthesis, or an allograft‐prosthetic composite, in addition to chemotherapy and/or radiation therapy . However, postoperative complications such as infection remain a significant clinical challenge, as periprosthetic joint infections (PJI) can result in the need for additional surgeries, amputation, and even death . While features such as age, size, location, histologic grade, and presence of pulmonary metastases can predict prognosis for patients with bone sarcomas, they represent static attributes that cannot be actively optimized to improve outcome.…”