Management of infection in systemic lupus erythematosus

Sciascia, Savino; Cuadrado, María J.; Karim, Mohammed Yousuf

doi:10.1016/j.berh.2013.07.002

Cited by 40 publications

(22 citation statements)

References 67 publications

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“…8,9 In systemic lupus erythematosus (SLE), treating patients with prednisone, even at moderate doses (median 7.5 mg per day), increases the risk of infection, whereas chloroquine-based antimalarial drugs have a protective effect. 10 The risk of pulmonary infection is particularly high for patients with an AIRD. In a study of 3,152 predominantly male US veterans aged 60 ± 10 years, the highest rate of hospitalization for infection was due to pneumonia (37%).…”

Section: Epidemiologymentioning

confidence: 99%

Vaccination of patients with autoimmune inflammatory rheumatic diseases

et al. 2014

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Patients with autoimmune inflammatory rheumatic diseases (AIRDs) are at increased risk of infections. This risk has been further increased by the introduction of biologic agents over the past two decades. One of the most effective strategies to prevent infection is vaccination. However, patients with an AIRD have a compromised immune system, which is further impaired by medication. Another important issue is the possibility of triggering a broad nonspecific response by vaccination, potentially resulting in increased activity of the underlying autoimmune disease. In this Review, we provide an analysis of data on vaccination of patients with an AIRD. Both the efficacy and the safety of vaccination are addressed, together with the epidemiology of vaccine-preventable infectious diseases in different subgroups of adults with AIRDs. Special attention is given to vaccination of patients who are treated with biologic agents.

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Section: Epidemiologymentioning

confidence: 99%

Vaccination of patients with autoimmune inflammatory rheumatic diseases

et al. 2014

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“…Despite the increased awareness about this problem, infections remain a major cause of morbidity and mortality in SLE affected patients [19].…”

Section: Discussionmentioning

confidence: 99%

Fasciolopsis buski infection in a Vietnamese pregnant woman with systemic lupus erythematosus

Fiamma

Longoni

Ngo

et al. 2015

J Infect Dev Ctries

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A clinical case of infection caused by Fasciolopsis buski in a 24 weeks pregnant woman from Vietnam affected by systemic lupus erythematosus (SLE) is reported here. On 22 February 2012 the patient was admitted to Hue Hospital in Hue, Vietnam, with a diagnosis of general illness and suspected acute anaemia. Laboratory analysis indicated possible SLE syndrome and coprological tests demonstrated the presence of F. buski eggs. During hospitalization the patient naturally eliminated the adult form in faeces suggesting the infection had already progressed at least for three months. One month after hospitalization due to the high severity of both SLE and fasciolopsiasis, a medical abortion was carried out and the following day the patient died. Even though infection due to Fasciolopsis buski is rare, this case highlights the importance of an accurate and prompt diagnosis of this infectious agent, which may have saved the foetus and mother's lives.

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“…In addition, infectious myositis can sometimes mimic inflammatory myositis. Although the pathogens that infect patients with SLE are often the same as those found in the general population, the clinical manifestations of infections can be atypical in patients with SLE 3. I report a case of PM that was caused by Klebsiella pneumoniae in a patient with SLE.…”

Section: Introductionmentioning

confidence: 98%

Pyomyositis in a patient with systemic lupus erythaematosus and a review of the literature

Meesiri

2016

BMJ Case Reports

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Pyomyositis (PM) is a common masquerading disease that is frequently misdiagnosed. A concurrent state of immunodeficiency is observed in up to 75% of tropical PM cases. PM in systemic lupus erythaematosus (SLE) is a relatively rare disease. I report a case of PM that was caused byKlebsiella pneumoniaein a patient with SLE who presented with leg pain, fever and a lupus flare-up. The patient was correctly diagnosed using a CT scan. Immediate surgical drainage was performed, and empirical antibiotics were administered. The patient was discharged while in a recovering condition. The clinical features, the results of radiographic investigations and the management of PM in SLE are synopsised in this article to underscore the importance of considering this relatively rare disease during differential diagnosis in patients with SLE with muscle pain with or without fever. I also emphasise the need to exclude mycobacterial infection in patients with SLE with PM.

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Management of infection in systemic lupus erythematosus

Cited by 40 publications

References 67 publications

Vaccination of patients with autoimmune inflammatory rheumatic diseases

Vaccination of patients with autoimmune inflammatory rheumatic diseases

Fasciolopsis buski infection in a Vietnamese pregnant woman with systemic lupus erythematosus

Pyomyositis in a patient with systemic lupus erythaematosus and a review of the literature

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