Management of Infections in Leukemia and Lymphoma

Young, Lowell S.

doi:10.1007/978-1-4615-6642-7_18

Cited by 20 publications

(4 citation statements)

References 112 publications

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“…In acute leukemia normal hematopoiesis is replaced by abnormal maturation and dysregulated proliferation of leukocytes (7). Coupled with significant bone marrow infiltration, this leads to decreased production of normal granulocytes resulting in neutropenia and impaired granulocyte function.…”

Section: Disease Specific Factors Associated With Host Immune Responsementioning

confidence: 99%

“…Coupled with significant bone marrow infiltration, this leads to decreased production of normal granulocytes resulting in neutropenia and impaired granulocyte function. Additionally, the presence of a large number of immature myeloid cells can inhibit antigen specific T cell response (8) Therefore, newly diagnosed leukemia patients often present with concurrent infections (7). Treatment with standard induction regimens results in prolonged neutropenia that can last weeks, rendering the host highly susceptible to bacterial and fungal infections (7).…”

Section: Disease Specific Factors Associated With Host Immune Responsementioning

confidence: 99%

“…Additionally, the presence of a large number of immature myeloid cells can inhibit antigen specific T cell response (8) Therefore, newly diagnosed leukemia patients often present with concurrent infections (7). Treatment with standard induction regimens results in prolonged neutropenia that can last weeks, rendering the host highly susceptible to bacterial and fungal infections (7). Furthermore, polymorphonuclear leucocyte function may be adversely affected by several chemotherapeutic medications such as high dose glucocorticoids, vincristine, vinblastine, carmustine, cyclophosphamide and 6-mercaptopurine (9).…”

Section: Disease Specific Factors Associated With Host Immune Responsementioning

confidence: 99%

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Infections in Leukemia

Chandran¹,

Hakki²,

Spurgeon³

2012

Sepsis - An Ongoing and Significant Challenge

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Section: Disease Specific Factors Associated With Host Immune Responsementioning

confidence: 99%

Section: Disease Specific Factors Associated With Host Immune Responsementioning

confidence: 99%

Section: Disease Specific Factors Associated With Host Immune Responsementioning

confidence: 99%

See 1 more Smart Citation

Infections in Leukemia

Chandran¹,

Hakki²,

Spurgeon³

2012

Sepsis - An Ongoing and Significant Challenge

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“…The rationale for this emphasis has been obvious: infection has been the major cause of death in patients being treated for hematologic malignancies and effects at curtailing or forestalling infection should have a beneficial impact on management of the underlying disease (1). Nevertheless, many, if not all, of the major approaches have been controversial, and those involving antimicrobial prophylaxis have provoked considerable debate (2,3).…”

mentioning

confidence: 99%

Antimicrobial prophylaxis in the neutropenic host: Lessons of the past and perspectives for the future

Lw¹

1988

Eur. J. Clin. Microbiol. Infect. Dis.

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Most attempts at preventing infection in neutropenic hosts have involved isolation of the patient from potential disease-causing microbes and the use of prophylatic antibiotics. Laminar airflow units were an expensive approach and the principal benefit may well have come from simultaneously administered regimens that suppressed the gut flora. The relationship between colonization of the gut by organisms that can subsequently cause systemic disease and gram-negative bacteremia has been supported by many observations, but the role of the normal anaerobic gastrointestinal flora in limiting overgrowth by potentially virulent gram-negative bacilli remains controversial. Cotrimoxazole has been a popular agent for prophylaxis but has serious deficiencies including lack of activity against Pseudomonas aeruginosa. Emergence of bacterial resistance to eotrimoxazole is an increasing problem. At present, the new fluoroquinolones offer promise as active agents against most gram-negative and some gram-positive pathogens but these agents lack antipneumocystis activity. It is widely perceived that improvements in clinical study design are needed in order to critically evaluate new developments in the field of antibiotic prophylaxis.

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Neutropenia: Antibiotic Combinations for Empiric Therapy

Young¹

1989

Perspectives in Antiinfective Therapy

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Management of Infections in Leukemia and Lymphoma

Cited by 20 publications

References 112 publications

Infections in Leukemia

Infections in Leukemia

Antimicrobial prophylaxis in the neutropenic host: Lessons of the past and perspectives for the future

Neutropenia: Antibiotic Combinations for Empiric Therapy

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