Management of iron deficiency

Ning, Shuoyan; Zeller, Michelle P.

doi:10.1182/hematology.2019000034

Cited by 85 publications

(98 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Iron is administrated at a dose of 4-6 mg/kg/day divided into three-times-a-day dose or single-daily dose on an empty stomach (2,9,15). Reticulocytosis starts on day 3 and reaches a peak in 5-7 days (16). Due to the rarity of pancytopenia in the context of iron deficiency, there is no clear evidence in the literature to determine the time to recovery of leukopenia and thrombocytopenia (4-6).…”

Section: Discussionmentioning

confidence: 99%

Pancytopenia as a Presentation of Iron Deficiency: A Case Report

et al. 2021

View full text Add to dashboard Cite

One of the most common nutritional deficiencies worldwide is iron deficiency. Fatigue, pallor, vertigo, dyspnea, cold intolerance, lethargy, palpitation, headache, and the pallor of the mucous membranes or nail beds are the most frequent symptoms and signs of iron deficiency. Thrombocytosis is commonly observed in iron deficiency anemia; it seems that erythropoietin plays the main role in this respect. Furthermore, thrombocytopenia and even leukopenia have been reported in iron deficiency; however, pancytopenia is a very rare condition. In this report, we presented two unusual cases of pancytopenia due to severe iron deficiency that improved after treatment with oral iron supplements. Iron deficiency anemia, if sufficiently severe, may be associated with reduced platelet and leukocyte counts. Accordingly, this condition should be considered as a differential diagnosis in all patients with pancytopenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Pancytopenia as a Presentation of Iron Deficiency: A Case Report

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Currently, three IV iron formulations (iron sucrose, ferric carboxymaltose, and iron isomaltoside) are most commonly used because they do not have serious side effects [26]. Many studies have compared the e cacy and safety of different IV iron formulations [27][28][29][30]. Derman et al [28] analyzed IV iron isomaltoside and IV iron sucrose administration and found that iron isomaltoside required fewer administrations and showed a higher and faster Hb response than iron sucrose administration.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Iron Administered the Day before Total Knee Arthroplasty Improves Postoperative Anemia Recovery

Kang

Jung

Kim

2021

Preprint

View full text Add to dashboard Cite

Background: Total knee arthroplasty (TKA) involves significant blood loss, which increases the risk for postoperative anemia and allogenic blood transfusion. Intravenous (IV) iron supplementation protects against postoperative anemia; however, the effectiveness of IV iron, given one day before TKA, on postoperative anemia and transfusion rates is unknown.Methods: A retrospective cohort study was conducted using two consecutive groups of patients who underwent TKA. One group received 500 mg iron isomaltoside intravenously one day before TKA (iron group, n=46), whereas the other group did not (non-iron group, n=46). After propensity score matching, transfusion rate, hemoglobin (Hb) level, ferritin and transferrin saturation, and rate of functional iron deficiency anemia (IDA) were compared at postoperative days (PODs) 2, 4, 6, and 14.Results: Age, sex, body mass index, and the American Society of Anesthesiologists Physical Status score did not differ between the groups. The iron group had higher Hb levels at POD 14 (p=0.021) and higher ferritin and transferrin saturation at PODs 2, 4, 6, and 14 than the non-iron group. The rate of functional IDA was significantly higher in the non-iron group than in the iron group at PODs 2 (p<0.001), 4 (p<0.001), 6 (p=0.001), and 14 (p=0.002). The rate of transfusion was not different between the groups (p=0.238).Conclusion: IV iron administered one day before TKA improved postoperative anemia recovery, but did not lower the postoperative transfusion rate. Because approximately half of the patients undergoing TKA experience postoperative functional IDA, clinicians should consider IV iron supplementation to improve iron availability.

show abstract

“…hemoglobin and myoglobin [10]. Fe deficiency is the predominant cause of anemia, affecting 27% of global population [11]. Fe deficiency and anemia lead to impaired cognitive development, immune suppression, fatigue, low-birth weight of infants, increased mortality and morbidity [12,13].…”

Section: Introductionmentioning

confidence: 99%

Genotype by Environment Interaction Effect on Grain Iron and Zinc Concentration of Indian and Mediterranean Lentil Genotypes

et al. 2021

View full text Add to dashboard Cite

Lentil grains with high nutritional value qualify as a promising candidate for alleviation of micronutrient malnutrition in South Asia and North Africa. Genetic variation for micronutrient concentration in germplasm is prerequisite for biofortification of this crop. In the present study, ninety-six lentil genotypes consisting of Indian (released varieties, advanced breeding lines and germplasm lines) and Mediterranean (germplasm lines and landraces) line were evaluated for grain iron (Fe) and zinc (Zn) concentrations and the stability of these traits was studied across three different locations in India. The pooled analysis of variance revealed significant genotype, environment and genotype by environment interaction (GEI) mean squares for both the micronutrients. Stability analysis employing the AMMI model elucidated the first two interaction principal components as significant and cumulatively explained 100% of GEI variation. The first two components explained 55.9% and 44.1% of the GEI sum of squares for grain iron and 50.8% and 49.2% for grain zinc concentration, respectively. No correlation between grain iron and zinc concentration was observed. Among 96 lines, genotypes IG 49, P 16214, ILL 147 and P 2118 were found to be relatively stable, having higher mean iron and zinc concentrations with low modified AMMI stability value (MASV), modified AMMI stability index (MASI) and genotype selection index (GSI). The identified promising genotypes (high Fe: P16214, IG 115, P 2127 and IC 560812 and high Zn: P 8115, P3234, LL 461 and IC 560812) can be utilized for studying the genetics of grain Fe and Zn concentration by developing mapping populations and for biofortification of Indian lentil.

show abstract

Management of iron deficiency

Cited by 85 publications

References 65 publications

Pancytopenia as a Presentation of Iron Deficiency: A Case Report

Pancytopenia as a Presentation of Iron Deficiency: A Case Report

Intravenous Iron Administered the Day before Total Knee Arthroplasty Improves Postoperative Anemia Recovery

Genotype by Environment Interaction Effect on Grain Iron and Zinc Concentration of Indian and Mediterranean Lentil Genotypes

Contact Info

Product

Resources

About