Management of isolated retroperitoneal Castelman’s disease: A case report

Ismail, Imen Ben; Zenaidi, Hakim; Yahmadi, Abdelwahed; Rebii, Saber; Zoghlami, Ayoub

doi:10.1016/j.ijscr.2020.03.048

Cited by 5 publications

(14 citation statements)

References 15 publications

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“…Besides, there is a possibility of spreading tumor cells and a risk of severe bleeding. Hence, the diagnosis is usually based on pathology after surgical resection [ 7 ]. Histologically, CD can be categorized into either hyaline-vascular type, plasma cell type or mixed type.…”

Section: Discussionmentioning

confidence: 99%

“…Some multicentric forms are associated with HSSV-8 or HIV infections [ 8 ]. The role of Interleukin 6 (IL6) has been reported in the genesis of MC disease [ 7 ]. Surgical resection is the gold standard treatment for UCD [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The role of Interleukin 6 (IL6) has been reported in the genesis of MC disease [ 7 ]. Surgical resection is the gold standard treatment for UCD [ 7 ]. In our case, the lesion was totally removed.…”

Section: Discussionmentioning

confidence: 99%

“…Mass reduction with neoadjuvant rituximab and radiotherapy can allow complete surgical resection with a lower morbidity [ 9 ]. If the resection is successful, prognosis is excellent [ 7 ]. Multicentric Castleman´s disease is more aggressive and has a poor prognosis [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Given that the disease is rare, there are no firm recommendations. Many agents have been tried, such as immunotherapy with monoclonal antibodies directed at IL-6 (siltuximab), antiviral agents when MCD is associated with HSSV-8 or HIV infections, and chemotherapeutic agents (doxorubicin, vincristine, cyclophosphamide, melphalan, and chlorambucil) [ 7 ]. MCD may progress to lymphoma, therefore a regular surveillance is mandatory [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Abdominal unicentric Castleman's disease: a case report

Bradai¹,

Khsiba²,

Nakhli³

et al. 2021

Pan Afr Med J

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Castleman's disease is a rare disease characterized by benign lymphoepithelial proliferation. There are two forms: unicentric and multicentric Castleman's disease. Mediastinal location is the most frequent. Intra-abdominal Castleman's disease is a rare presentation. We report a case of 65-year-old female who presented with epigastric pain. Investigations revealed a retroperitoneal mass which was surgically resected. Histopathological examination showed hyaline-vascular type Castleman's disease. In conclusion, Castelman´s disease is a diagnostic challenge and it must be included in the differential diagnosis of retroperitoneal tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Abdominal unicentric Castleman's disease: a case report

Bradai¹,

Khsiba²,

Nakhli³

et al. 2021

Pan Afr Med J

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Castleman Disease with MDM2/CDK4 Protein Expression: a Potential Mimic of Inflammatory Variant of Liposarcoma with Significant Consequences

et al. 2022

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Castleman disease is a rare benign lymphoproliferative disorder that includes a spectrum of distinct histopathological entities. The differential diagnosis of Castleman disease is broad and includes lymphomas, HIV-related lymphadenopathy, autoimmune disorders, and inflammatory liposarcoma. When Castleman disease occurs in the retroperitoneum, the distinction from the inflammatory variant of well-differentiated liposarcoma can be very challenging in small biopsies. Herein we report a case of Castleman disease that presented as a retroperitoneal mass and expressed MDM2 and CDK4 by immunohistochemistry. To our knowledge, this is the first report of Castleman disease staining positively for MDM2/CDK4, and it underscores how immunohistochemistry can potentially serve as a pitfall when differentiating this rare entity from retroperitoneal sarcomas.

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Intraperitoneal hyaline vascular Castleman disease: Three case reports

Gao,

Shi,

Zhu

et al. 2023

World J Clin Cases

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BACKGROUND Castleman disease (CD) was first reported in 1954. It is a rare non-malignant lymphoproliferative disease with unclear etiology. As the clinical manifestations of CD are different, there are difficulties in its diagnosis and treatment. Therefore, for patients with CD, it is important to establish the diagnosis in order to choose the appropriate treatment. CASE SUMMARY In this report, three patients with intraperitoneal CD treated at our center from January 2018 to June 2023 were reviewed, and the clinical and paraclinical examinations, diagnosis, and treatment were analyzed, and all three patients were diagnosed with CD by routine histopathological and immunohistochemical examinations. CONCLUSION CD is a complex and rare disease. Because there are no special clinical symptoms and laboratory abnormalities, the diagnosis often depends on routine pathological and immunohistochemical findings.

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Management of isolated retroperitoneal Castelman’s disease: A case report

Cited by 5 publications

References 15 publications

Abdominal unicentric Castleman's disease: a case report

Abdominal unicentric Castleman's disease: a case report

Castleman Disease with MDM2/CDK4 Protein Expression: a Potential Mimic of Inflammatory Variant of Liposarcoma with Significant Consequences

Intraperitoneal hyaline vascular Castleman disease: Three case reports

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