Background: Cercospora leaf spot of mothbean caused by Cercospora canescens Ellis and Martin is one of the most important fungal diseases causing damage to the crop. C. canescens causes losses to yield in major Mothbean growing areas of Rajasthan. Its affects the foliation and in severe infection damaged entire crop that lead to yield loss up to 50-70%. In this, Check the efficacy of new molecules available in the market should be analyzed with this disease. Methods: Nine fungicides were tested at four concentrations (50, 100, 150 and 200 ppm) under in vitro conditions with CRD design against C. canescens and also tested under field conditions. The field experiment was conducted at Research Farm of College of Agriculture, SKRAU, Bikaner, during Kharif 2019 in RBD design with the application of foliar spray of nine different fungicides at different concentrations against Cercospora leaf spot disease of mothbean. Result: Among these new molecule fungicides tested, trifloxystrobin 25% + tebuconazole 50% WG and carbendazim 12% + mancozeb 63% WP was highly effective with maximum inhibition of mycelial growth (100.00%) at 200 ppm concentrations. The results of in vivo studies revealed that spraying with 0.15% trifloxystrobin 25% + tebuconazole 50% WG helped to manage the leaf spot successfully and reduced the disease intensity (15.51%) with disease control (72.71%) and recorded highest yield (8.10 q ha-1) effective under field conditions as foliar spray at appropriate time.