Management of Locally Advanced Breast Cancer

Yadav, Dinesh Kumar; Shukla, Nootan Kumar; Mishra, Mayank

doi:10.1007/978-981-16-4546-4_16

Cited by 1 publication

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 The pathological response to neoadjuvant chemotherapy, which is demonstrated by complete or almost complete tumour eradication in the surgical specimen, is thought to be a powerful predictor of survival and an indication of a good overall prognosis. 8 Patients with locally advanced, operable breast cancer frequently get neoadjuvant chemotherapy (NAC) to get rid of micrometastases before surgery.…”

Section: Resultsmentioning

confidence: 99%

Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study

Mahmoud,

Ali,

Khattab

et al. 2023

Ain Shams Journal of Surgery

View full text Add to dashboard Cite

Background: Breast cancer affects millions of people globally each year, making it a major health concern. The management of breast cancer has undergone a significant transformation with the introduction of neoadjuvant chemotherapy (NACT).Aim and objectives: Neoadjuvant chemotherapy and upfront surgery for breast cancer were compared in terms of clinicopathological characteristics, surgical techniques, and outcome metrics with the goal of comparing the outcomes in term of local recurrence rates and metastasis in 2 groups.Subjects and methods: This is a comparative research, which included (40) women who had been diagnosed with breast cancer and were split into two groups: In group A: 20 patients underwent upfront surgery, Group B: 20 patients recieved neo adjuvant chemotherapy over a year. Result:The two study groups differed statistically significantly in terms of local recurrence and metastatic work up. Conclusion:Neoadjuvant chemotherapy significantly increases the risk of metastasis compared to upfront surgery while having a marginally positive effect on pathological complete response (PCR) in patients with breast cancer. We discovered that upfront surgery is preferable in the treatment of early breast cancer, but neoadjuvant chemotherapy is preferable in the treatment of late breast cancer.

show abstract

Section: Resultsmentioning

confidence: 99%