Management of macular holes that develop after retinal detachment repair

Moshfeghi, Andrew A; Salam, Gohar A.; Deramo, Vincent A; Shakin, Eric; Ferrone, Philip J.; Shakin, Jeffrey L.; Fastenberg, David M.

doi:10.1016/s0002-9394(03)00572-5

Cited by 48 publications

(45 citation statements)

References 21 publications

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“…Subretinal injections in the proximity of the fovea are expected to cause the largest separation between the neural retina and the RPE, one of the factors related to visual acuity recovery after retinal detachment with foveal involvement (Ross et al, 2005). Epiretinal membrane contraction, a common feature of retinal degenerations , has been mentioned as a possible cause of the macular hole in patient 2 of Maguire and coworkers (2008) but is unlikely to be the sole determinant of this complication (Moshfeghi et al, 2003).…”

Section: Figmentioning

confidence: 99%

Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

et al. 2008

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Leber congenital amaurosis (LCA) is a group of autosomal recessive blinding retinal diseases that are incurable. One molecular form is caused by mutations in the RPE65 (retinal pigment epithelium-specific 65-kDa) gene. A recombinant adeno-associated virus serotype 2 (rAAV2) vector, altered to carry the human RPE65 gene (rAAV2-CB SB -hRPE65), restored vision in animal models with RPE65 deficiency. A clinical trial was designed to assess the safety of rAAV2-CB SB -hRPE65 in subjects with RPE65-LCA. Three young adults (ages 21-24 years) with RPE65-LCA received a uniocular subretinal injection of 5.96 ϫ 10 10 vector genomes in 150 l and were studied with follow-up examinations for 90 days. Ocular safety, the primary outcome, was assessed by clinical eye examination. Visual function was measured by visual acuity and dark-adapted full-field sensitivity testing (FST); central retinal structure was monitored by optical coherence tomography (OCT). Neither vector-related serious adverse events nor systemic toxicities were detected. Visual acuity was not significantly different from baseline; one patient showed retinal thinning at the fovea by OCT. All patients self-reported increased visual sensitivity in the study eye compared with their control eye, especially noticeable under reduced ambient light conditions. The dark-adapted FST results were compared between baseline and 30-90 days after treatment. For study eyes, sensitivity increases from mean baseline were highly significant (p Ͻ 0.001); whereas, for control eyes, sensitivity changes were not significant (p ϭ 0.99). Comparisons are drawn between the present work and two other studies of ocular gene therapy for RPE65-LCA that were carried out contemporaneously and reported. 979

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Section: Figmentioning

confidence: 99%

Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

et al. 2008

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“…[3][4][5] Bu olgu sunumunda y›rt›kl› retina dekolman› nedeniyle skleral çökertme cerrahisi uygulanan ve postoperatif dö-nemde makula deli¤i geliflimi izlenen bir olgu tart›fl›l-maktad›r.…”

Section: 2unclassified

“…1,2 Retina dekolman› cerrahisi sonras› makula deli¤i geliflimi oldukça nadir bir durum olarak rapor edilmifltir. [3][4][5] Bu olgu sunumunda y›rt›kl› retina dekolman› nedeniyle skleral çökertme cerrahisi uygulanan ve postoperatif dö-nemde makula deli¤i geliflimi izlenen bir olgu tart›fl›l-maktad›r.…”

Section: Giriflunclassified

“…3 Makula yüzeyindeki tanjansiyel çekintinin temel neden oldu¤u ve baz› durumlarda da ön-arka çekintinin de rol oynayabilece¤i düflü-nülmektedir. ‹lk kez Kelly ve Wendel 6 vitrektomi cerrahisi, intraoküler gaz tamponad› ve yüzafla¤› postür ile makula deliklerinin tedavi edilebilece¤ini göstermifllerdir.…”

Section: Olgu Sunumuunclassified

“…3,4 Bu komplikasyon skleral çökertme, pnömatik retinopeksi ve hatta vitrektomi cerrahisi sonras›nda bildirilmifltir. Literatürdeki olgular›n ço¤u skleral çökertme cerrahisi sonras› geliflen olgulard›r ve hastalar›n hemen tamam› makulas› tutulmufl dekolman olgular›d›r.…”

Section: Olgu Sunumuunclassified

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Macular Hole Development Following Conventional Retinal Detachment Surgery and its Treatment: A Case Report

Tatlıpınar¹,

Kohen²,

Başar³

2011

tjo

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Ö z e tRetina dekolman cerrahisi sonras› makula deli¤i geliflimi yay›nlanan çal›flmalarda nadir bir komplikasyon olarak bildirilmektedir. Bu yaz›da, makulas› tutulmufl bir y›rt›kl› retina dekolman› olgusunda baflar›l› bir skleral çökertme ve intravitreal gaz enjeksiyonu operasyonu sonras› geliflen makula deli¤i ve tedavisi sunulmaktad›r. ( GiriflMakula deli¤i (MD), foveada tam kat defektle karakterize bir durum olup en s›k tipi idiyopatik oland›r. Olgular›n ço¤u 50 yafl üstü olup kad›nlarda daha s›kt›r. Makula deliklerinin di¤er nedenleri aras›nda yüksek miyopi ve travma say›labilir. ‹diyopatik makula deliklerini patogenezi tam olarak anlafl›lamasa da temel patofizyolojik mekanizman›n vitreomaküler arayüzeydeki çekinti oldu¤u öne sürülmektedir. 1,2Retina dekolman› cerrahisi sonras› makula deli¤i geliflimi oldukça nadir bir durum olarak rapor edilmifltir. [3][4][5] Bu olgu sunumunda y›rt›kl› retina dekolman› nedeniyle skleral çökertme cerrahisi uygulanan ve postoperatif dö-nemde makula deli¤i geliflimi izlenen bir olgu tart›fl›l-maktad›r. Olgu Sunumu‹ki haftad›r sa¤ gözde az görme yak›nmas›yla baflvuran 61 yafl›ndaki erkek hastan›n görme keskinli¤i parmak sayma düzeyinde olup yap›lan fundus muayenesinde makulay› tutan y›rt›kl› retina dekolman› görüldü. Y›rt›k üst temporal kadranda yerleflmifl olup retina üst kadranda dekole idi. Makulada delik izlenmedi. Hasta bilateral belirgin katarakt› yoktu ve sol gözde görmesi düzeltmesiz tamd›. Genel anestezi alt›nda sa¤ göze 360 0 sörklaj cerrahisi ve intravitreal gaz enjeksiyonu (0,35 cc saf SF6) uyguland› ve postoperatif postür verildi. Postoperatif 1. günde görme 0,16 seviyesine ç›km›flt› ve retina yat›fl›k olup makulada delik izlenmedi. Poliklinik flartlar›nda y›rt›k çevresine baraj lazer fotokoagülasyon uyguland›. Olgu-

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Macular Hole Surgery

Iezzi

Ferenchak

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Management of macular holes that develop after retinal detachment repair

Cited by 48 publications

References 21 publications

Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

Macular Hole Development Following Conventional Retinal Detachment Surgery and its Treatment: A Case Report

Macular Hole Surgery

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