2005
DOI: 10.1093/jjco/hyi019
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Management of Malignant Pericardial Effusion with Instillation of Mitomycin C in Non-small Cell Lung Cancer

Abstract: Intrapericardial instillation of 2 mg of mitomycin C was feasible and demonstrated a promising response against malignant pericardial effusion resulting from non-small cell lung cancer.

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Cited by 23 publications
(19 citation statements)
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“… 14 Talcage involves instilling a sclerosing agent with the intention of scarring the pericardium to the epicardium. Multiple agents have been studied including Tetracycline and Doxycycline, 15 Minocycline, 16 Thiotepa, 17 , 18 platinum derivatives, 19 – 21 Mitoxantrone, 22 Mitomycin C, 23 and Bleomycin. 24 – 26 Success rates (expressed as no reaccumulation at 30 days) range from 70% to 90%.…”
Section: Introductionmentioning
confidence: 99%
“… 14 Talcage involves instilling a sclerosing agent with the intention of scarring the pericardium to the epicardium. Multiple agents have been studied including Tetracycline and Doxycycline, 15 Minocycline, 16 Thiotepa, 17 , 18 platinum derivatives, 19 – 21 Mitoxantrone, 22 Mitomycin C, 23 and Bleomycin. 24 – 26 Success rates (expressed as no reaccumulation at 30 days) range from 70% to 90%.…”
Section: Introductionmentioning
confidence: 99%
“…Unlike other malignant effusions, those caused by NSCLC have low sensitivity to chemo-and radiotherapy [84][85][86]; therefore these patients are candidates for palliative therapy. In a similar way, NSCLC is the most frequent cause of malignant pericardial effusion, which has a grim prognosis too [87][88][89].…”
Section: Pl3mentioning
confidence: 95%
“…Agents including bleomycin, carboplatin, cisplatin, and mitomycin-C have been used for this purpose (Kaira et al, 2005;Maisch, Ristic, and Pankuweit, 2010;Maruyama et al, 2007;Moriya et al, 2000). Systemic chemotherapy may be helpful.…”
Section: Managementmentioning
confidence: 99%