Management of meningeal solitary fibrous tumors/hemangiopericytoma; surgery alone or surgery plus postoperative radiotherapy?

Haas, Rick L.; Walraven, Iris; Lecointe-Artzner, Estelle; Houdt, Winan J. van; Scholten, Astrid N.; Strauß, D.; Schrage, Yvonne; Hayes, Andrew; Raut, Chandrajit P.; Fairweather, Mark; Baldini, E.H.; Gronchi, Alessandro; Rosa, Laura De; Griffin, Anthony M.; Ferguson, Peter C.; Wunder, Jay S.; Sande, Michiel A. J. van de; Krol, Augustinus D.G.; Skoczylas, Jacus; Brandsma, Dieta; Doglietto, Francesco; Sangalli, Claudia; Stacchiotti, Silvia

doi:10.1080/0284186x.2020.1826574

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…Adjuvant radiotherapy has usually been recommended in meningeal SFT, and even when no prospective study has been addressed, retrospective analysis suggests a clear trend toward significantly better local control if radiation therapy is added in the adjuvant setting. The 5-year local control in 89 patients was 60% vs. 90%, p = 0.052, favoring the postoperative radiotherapy (RT) group [105].…”

Section: Treatment In Sft 81 Surgery and Radiation Therapymentioning

confidence: 99%

A Comprehensive Review on Solitary Fibrous Tumor: New Insights for New Horizons

Martin‐Broto

Mondaza-Hernandez

Moura

et al. 2021

Cancers

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Solitary fibrous tumor (SFT) is a rare mesenchymal, ubiquitous tumor, with an incidence of 1 new case/million people/year. In the 2020 WHO classification, risk stratification models were recommended as a better tool to determine prognosis in SFT, to the detriment of “typical” or “malignant” classic terms. The risk for metastasis is up to 35–45%, or even greater, in series with a longer follow-up. Over the last few decades, advances in immunohistochemistry and molecular diagnostics identified STAT6 nuclear protein expression and the NAB2–STAT6 fusion gene as more precise tools for SFT diagnosis. Recent evidence taken from retrospective series and from two prospective phase II clinical trials showed that antiangiogenics are active and their sequential use from first line should be considered, except for dedifferentiated SFT for which chemotherapy is the best option. Since the fusion transcript driver’s first description in 2013, new insights have been brought on key molecular events in SFT. This comprehensive review mainly focuses on the superior efficacy of antiangiogenics over chemotherapeutic agents in SFT, provides the current knowledge of key molecules that could co-drive the SFT behavior, and suggests new target candidates that deserve to be explored in preclinical and clinical research in SFT.

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Section: Treatment In Sft 81 Surgery and Radiation Therapymentioning

confidence: 99%

A Comprehensive Review on Solitary Fibrous Tumor: New Insights for New Horizons

Martin‐Broto

Mondaza-Hernandez

Moura

et al. 2021

Cancers

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“…Whether and when to perform adjuvant radiotherapy is still a matter of debate. There is evidence that adjuvant radiotherapy for both extrameningeal and meningeal SFT may improve local control [ 27 , 32 , 33 , 34 ]. However, adjuvant radiotherapy does not prevent the development of neuroaxis or peripheral metastases [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Spinal Solitary Fibrous Tumors: An Original Multicenter Series and Systematic Review of Presentation, Management, and Prognosis

Apra

Arbi

Montero

et al. 2022

Cancers

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All solitary fibrous tumors (SFT), now histologically diagnosed by a positive nuclear STAT6 immunostaining, represent less than 2% of soft tissue sarcomas, with spinal SFT constituting a maximum of 2% of them, making these tumors extremely rare. We provide an up-to-date overview of their diagnosis, treatment, and prognosis. We included 10 primary STAT6-positive SFT from our retrospective cohort and 31 from a systematic review. Spinal pain was the most common symptom, in 69% of patients, and the only one in 34%, followed by spinal cord compression in 41%, radicular compression, including pain or deficit, in 36%, and urinary dysfunction specifically in 18%. Preoperative diagnosis was never obtained. Gross total resection was achieved in 71%, in the absence of spinal cord invasion or excessive bleeding. Histologically, they were 35% grade I, 25% grade II, and 40% grade III. Recurrence was observed in 43% after a mean 5.8 years (1 to 25). No significant risk factor was identified, but adjuvant radiotherapy improved the recurrence-free survival after subtotal resection. In conclusion, spinal SFT must be treated by neurosurgeons as part of a multidisciplinary team. Owing to their close relationship with the spinal cord, radiotherapy should be considered when gross total resection cannot be achieved, to lower the risk of recurrence.

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“…Recently, some Authors have investigated the role of systemic therapies and postoperative radiotherapy in advanced SFTs, suggesting that combining radiotherapy to surgery may reduce the risk for local recurrence (3,21). These studies are promising but a greater number of patients is required to find the most efficacious preoperative, intraoperative or postoperative chemo or radiotherapy regimen.…”

Section: Discussionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Seminal Vesicle: A Systematic Literature Review and Case Presentation

Crocetti

Sapienza

Lamazza

et al. 2021

In Vivo

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Background/Aim: Solitary fibrous tumors (SFTs) are ubiquitous mesenchymal neoplasms that have an unpredictable biological behavior. Histological criteria for this type of malignancy are uncertain. Clinical characteristics, diagnostic and treatment options of SFTs originating in the seminal vesicle are presented in this review article. Materials and Methods: A systematic review including the following databases: Scopus, Embase and Medline from 1960 until the end of March 2021 was performed according to the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. Results: We found seven patients affected with SFTs of seminal vesicle, in which we added our own case, making a total of 8 patients. Mean age at presentation was 55±7 years. Mean size of the SFTs was 9±2 cm and the right seminal vesicle was preferentially involved. The majority of patients were symptomatic and presenting symptoms were hematuria, dysuria, hematospermia, urinary increased frequency and urgency. Abdominal ultrasonography, computed tomography (CT) scan, and magnetic resonance (MRI) were the diagnostic tools. Trans-rectal ultrasound-guided core biopsy was also used. Seven (87%) patients had open surgery. Adjuvant radiotherapy after R0 resection was used in 1 patient. Conclusion: The treatment of SFTs located in the seminal vesicle necessitates a radical surgical resection to obtain acceptable results in terms of local recurrence and distant metastases.

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Management of meningeal solitary fibrous tumors/hemangiopericytoma; surgery alone or surgery plus postoperative radiotherapy?

Cited by 18 publications

References 41 publications

A Comprehensive Review on Solitary Fibrous Tumor: New Insights for New Horizons

A Comprehensive Review on Solitary Fibrous Tumor: New Insights for New Horizons

Spinal Solitary Fibrous Tumors: An Original Multicenter Series and Systematic Review of Presentation, Management, and Prognosis

Solitary Fibrous Tumor of the Seminal Vesicle: A Systematic Literature Review and Case Presentation

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