Management of meningiomas

Alexiou, George Α.; Gogou, Pinelopi; Markoula, Sofia; Kyritsis, Athanasios P.

doi:10.1016/j.clineuro.2009.12.011

Cited by 127 publications

(113 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some remain unaltered in size for a long period, while others tend to grow fast (10). Surgical resection remains the treatment mainstay (1,24). In benign meningiomas total excision is associated with favorable prognosis, provided that complete tumor excision has been performed.…”

Section: Discussionmentioning

confidence: 99%

“…About 2-3% of the population has been reported to have an incidental meningioma (18). Even if the majority of meningiomas have benign histological features and complete removal is associated with good prognosis, atypical and malignant meningiomas constitute nearly 6% and 2% of cases, respectively, and have been linked with increased risk of recurrence (1,13,14).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of stem cell marker nestin and microrna-21 in meningiomas

Galani

Alexiou²,

Miliaras³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

AIm: Meningiomas are one of the most common benign intracranial tumors, making up nearly one third of all primary intracranial tumors. The majority of meningiomas have benign histological features and total resection is associated with favourable prognosis. Atypical and malignant meningiomas are associated with increased risk of recurrence. In the present study we set out to investigate the role of nestin mRNA levels and miR-21 in meningiomas. mATeRIAL and meTHods:We studied 17 patients with meningiomas that were treated surgically in our institute. Clinical variables that were analyzed were age, sex and histology. The expression of stem cell marker nestin mRNA levels and miR-21 was investigated in tissue samples by qRT-PCR.ResuLTs: Considerable levels of both miR-21 and nestin mRNA were found. Atypical and anaplastic meningiomas had higher expression of both miR-21 and nestin compared to benign tumors. Furthermore, a trend towards a positive correlation between miR-21 and nestin mRNA levels was also found.CoNCLusIoN: Increased miR-21 and nestin mRNA levels were found in anaplastic meningiomas, in which recurrence is common, and the role of miR-21 and Nestin in meningiomas therefore warrants further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of stem cell marker nestin and microrna-21 in meningiomas

Galani

Alexiou²,

Miliaras³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

show abstract

“…4,12 In these patients, even if a GTR is not achieved, meningiomas are usually highly responsive to stereotactic radiosurgery with low associated complication rates, and adjuvant stereotactic radiosurgery can be performed if necessary. 1,7 Despite the many advantages offered by the ETSA, the drawbacks are also numerous and significant. Perhaps the most well-known drawback is the chance of CSF leakage, which can occur with the removal of bone and dura underlying the tumor.…”

Section: Advantages and Disadvantages Of Tcr And Etsamentioning

confidence: 99%

“…5 In these patients, even if a GTR or NTR is not achieved, stereotactic radiosurgery has been well proven to provide good control of typical meningiomas, with one recent paper demonstrating 87% control for skull base meningiomas. 1 Evaluating lateral extension of the TSM is critical in selecting the correct approach. 10 The tumor recurrence in the patient in Case 13 illustrates the importance of selecting tumors for ETSA that remain medial to the supraclinoid internal carotid arteries and optic nerves.…”

Section: Choice Of Surgical Approachmentioning

confidence: 99%

Surgical decision-making strategies in tuberculum sellae meningioma resection

Bowers

Altay²,

Couldwell³

2011

FOC

View full text Add to dashboard Cite

Object Although the transcranial route (TCR) has been the traditional approach for removing tuberculum sellae meningiomas (TSMs), the use of the microscopic and/or more recently the endoscopic transsphenoidal approach (ETSA) has gained acceptance for selected cases. In this study, the authors present their experience with the ETSA and the TCR and examine the criteria most important for deciding the optimal approach in a particular case. Methods The authors retrospectively reviewed recent cases of TSMs treated surgically by the senior author via either the TCR or the ETSA or both. Demographic information, clinical presentation, and clinical and radiological outcomes of the patients were evaluated. Results Twenty-seven patients underwent removal of a TSM during a recent period. Gross-total or near-total resection was achieved in 20 (91%) of 22 patients who underwent resection via the TCR and in 3 (60%) of 5 patients who underwent the ETSA. Among the patients in whom gross- or near-total resection was achieved, recurrence was observed in only 1 patient, whose tumor was removed via the ETSA. Conclusions In the majority of patients, the TCR provided complete resection of the tumor without compromising the safety of the procedure. In select cases of tumors with a reasonable size and location (midline and/or extending into the sphenoid sinus) as well as no involvement of inaccessible neurovascular and bony elements via this approach, the ETSA could also be a viable option.

show abstract

“…1 As parasellar cavernous haemangiomas are rare, they are frequently misdiagnosed as meningiomas and subsequently resected, 1 but correct preoperative diagnosis allows for more appropriate treatment (radiation therapy rather than surgical resection). [7][8][9][10][11][12] The MRI techniques of diffusion weighted imaging (DWI) and perfusion imaging have added a new dimension of physiological information to the anatomical data provided by conventional diagnostic imaging. 13 When the gross appearance of lesions is similar on DWI, the calculated apparent diffusion coefficient (ADC) is used to provide a more quantitative approach.…”

Section: Introductionmentioning

confidence: 99%

The role of magnetic resonance diffusion-weighted imaging and three-dimensional arterial spin labelling perfusion imaging in the differentiation of parasellar meningioma and cavernous haemangioma

et al. 2014

View full text Add to dashboard Cite

Objective: To evaluate the diagnostic value of magnetic resonance diffusion-weighted imaging (DWI) and three-dimensional arterial spin labelling perfusion imaging (3D-ASL) in distinguishing cavernous haemangioma from parasellar meningioma, using histological data as a reference standard. Methods: Patients with parasellar meningioma or parasellar cavernous haemangioma underwent conventional T 1 -and T 2 -weighted magnetic resonance imaging (MRI) followed by DWI and 3D-ASL using a 3.0 Tesla MRI. The minimum apparent diffusion coefficient (minADC) from DWI and the maximal normalized cerebral blood flow (nCBF) from 3D-ASL were measured in each tumour. Diagnosis was confirmed by histology. Results: MinADC was significantly lower and nCBF significantly higher in meningioma (n ¼ 19) than cavernous haemangioma (n ¼ 15). There was a significant negative correlation between minADC and nCBF (r ¼ À0.605). Conclusion: DWI and 3D-ASL are useful in differentiating cavernous haemangiomas from parasellar meningiomas, particularly in situations when the appearance on conventional MRI sequences is otherwise ambiguous.

show abstract

Management of meningiomas

Cited by 127 publications

References 89 publications

Expression of stem cell marker nestin and microrna-21 in meningiomas

Expression of stem cell marker nestin and microrna-21 in meningiomas

Surgical decision-making strategies in tuberculum sellae meningioma resection

The role of magnetic resonance diffusion-weighted imaging and three-dimensional arterial spin labelling perfusion imaging in the differentiation of parasellar meningioma and cavernous haemangioma

Contact Info

Product

Resources

About