Management of non‐lymphomatous small intestinal tumours in dogs and cats

Shales, Chris

doi:10.1136/inp.h259

Cited by 5 publications

(8 citation statements)

References 33 publications

(80 reference statements)

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“…Mast cell tumours are the third most common small intestinal neoplasia in cats (Shales ). Both mast cell tumours in this study would have been fully excised with 5 cm histological margins.…”

Section: Discussionmentioning

confidence: 99%

“…To obtain complete excision of intestinal tumours in cats, surgical margins from as narrow as 2 cm to as wide as 8 cm have been recommended (White ; North & Banks ; Bray ; Marconato & Bettini ). However, there is a lack of clinical data and research to substantiate these recommendations (Shales ).…”

Section: Introductionmentioning

confidence: 99%

“…). Reasons to consider surgical resection for intestinal lymphoma include gaining a histopathological diagnosis (Shales ), preventing or treating intestinal obstruction (MacPhail ) or perforation (Selting ). There is also a risk that a single discrete intestinal lymphoma may rupture with chemotherapy making surgery justifiable in these cases (Ettinger ).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the histopathological extent of neoplastic infiltration in intestinal tumours in cats

Morrice¹,

Polton

Beck³

2019

Veterinary Medicine & Sci

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With the exception of intestinal lymphoma, surgery is the most commonly recommended treatment for solitary feline intestinal tumours. However, there is a lack of evidence to substantiate resection margin recommendations for these tumours. The aim of this study was to add knowledge concerning resection margins for discrete intestinal masses in cats. Thirty confirmed feline intestinal tumours removed at veterinary centres across the UK from March 2017 to March 2018 underwent histological assessment at the palpable edge of the intestinal tumour and then at every 1 cm increment to the surgeon‐cut tissue border in oral, aboral and mesenteric directions. Histological margin recommendations were developed for carcinoma and lymphoma tumour types and non‐lymphoma intestinal tumours collectively. Seventeen intestinal lymphomas, nine carcinomas, two sarcomas and two mast cell tumours were evaluated in this study. Seven of the nine intestinal carcinomas would have been completely removed with histological margins of 4 cm in oral and aboral directions. Both sarcomas and one mast cell tumour would have been removed in their entirety with 4 cm histological margins in oral and aboral directions. There was extensive and varied microscopic invasion of intestinal tissue away from discrete intestinal lymphomas in the majority of the cases in this study. There is increasing evidence in veterinary as well as human literature supporting the role of surgical resection in the treatment of discrete intestinal lymphoma. If surgery is to be considered this study supports the removal of the gross tumour only. A histological margin of 4 cm should be considered, where possible, for intestinal masses other than lymphomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the histopathological extent of neoplastic infiltration in intestinal tumours in cats

Morrice¹,

Polton

Beck³

2019

Veterinary Medicine & Sci

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“…Surgery is the recommended treatment option for intestinal masses with the current exception of lymphoma (Shales 2015). Lymphoma is usually treated with chemotherapy unless there is perforation, the need for a biopsy or intestinal obstruction (Culp et al 2012;Selting 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the extent of neoplastic infiltration in small intestinal tumours in dogs

Morrice¹,

Polton

Beck³

2019

Veterinary Medicine & Sci

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There is currently a lack of evidence‐based guidance when determining surgical margins for small intestinal tumours in dogs. The purpose of this study is to help the surgeon make informed clinical decisions about margins when confronted with a small intestinal mass. Twenty‐seven canine small intestinal tumours were histologically diagnosed and then had further histological assessment at every centimeter from the edge of the palpable tumour to the surgical margin in oral, aboral and mesenteric directions. In all 10 carcinomas a 3 cm tissue margin in oral, aboral and mesenteric directions would have resulted in complete tumour resection. In all 11 sarcomas a 2 cm tissue margin in oral, aboral and mesenteric directions would have resulted in complete tumour resection. Five of the six intestinal lymphomas would have required tissue margins of 4 cm or more for complete resection. Of the 21 non‐lymphoma tumours assessed in this study, complete resection was achieved in all 21 (100%) with tissue margins at 3 cm from the palpable edge of the mass, 20 (95%) with tissue margins at 2 cm from the palpable edge of the mass, and 16 (76%) with tissue margins at 1 cm from the palpable edge of the mass in oral and aboral directions. All non‐lymphoma canine small intestinal masses will be completely resected when tissue margins are 3 cm from the palpable edge of the mass in oral and aboral directions after fixation in formalin.

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“…Gastrointestinal tumours other than lymphoma are rare in cats, with adenocarcinomas seen more commonly than mesenchymal tumours . Gastrointestinal stromal cell tumours (GISTs) are a subset of mesenchymal tumours that are thought to arise from the interstitial cells of Cajal, and require immunohistochemistry to differentiate from other mesenchymal tumours . GISTs stain positive for KIT protein (CD117), a receptor tyrosine kinase encoded by the proto‐oncogene c‐KIT, while leiomyomas or leiomyosarcomas are negative for CD117 but positive for smooth muscle actin (SMA) or desmin .…”

mentioning

confidence: 99%

Management of a feline gastric stromal cell tumour with toceranib phosphate: a case study

McGregor¹,

Moore²,

Yeomans³

2020

Aust Veterinary J

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Background A fifteen‐year old, female spayed domestic longhaired cat was presented for a routine vaccination during which an incidental abdominal mass was palpated. After further inquiry, occasional vomiting was reported to occur once every few weeks to months, associated with no other gastrointestinal signs. Case report Ultrasonography revealed a gastric mass. Histopathology and immunohistochemistry confirmed a CD117 positive, smooth muscle actin and desmin negative neoplasm, consistent with a gastrointestinal stromal cell tumour (GIST). Treatment was initiated with toceranib phosphate resulting in stable disease for over eighteen months, and the patient was still alive at the time of writing. Conclusion GISTs are rare in cats and this is the first report of medical management of feline GIST using toceranib.

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Management of non‐lymphomatous small intestinal tumours in dogs and cats

Cited by 5 publications

References 33 publications

Evaluation of the histopathological extent of neoplastic infiltration in intestinal tumours in cats

Evaluation of the histopathological extent of neoplastic infiltration in intestinal tumours in cats

Evaluation of the extent of neoplastic infiltration in small intestinal tumours in dogs

Management of a feline gastric stromal cell tumour with toceranib phosphate: a case study

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