Management of Obesity by Using CLA and Omega 3, 6,9 as Combined Therapy

Many people suffer from ulcer, a disorder of the digestive tract. Simply put, it's an inflamed break in the skin or the mucus membrane lining the digestive tract. Whenever there is a change in the equilibrium, such as increased aggression or decreased mucosal resistance, ulceration develops. Reasons for this could include drug use, poor diet, stress, and other similar factors. Peptic ulcers are a general term for any type of stomach or duodenal ulcer. To develop, peptic ulcers need mucosal defences to be compromised in addition to gastric juice acid and peptic activity. Ulcers can be treated with a variety of synthetic medications. However, compared to herbal remedies, these drugs are more costly and more likely to cause side effects. According to the research, many different ayurvedic doctors and traditional medicine practitioners use different medicinal plants and polyherbal formulations to treat ulcers. Peptic ulcer disease treatment should focus on symptom alleviation, ulcer healing, and preventing recurrence. In this article, we'll take a look at some medicinal plants that have been studied for their potential use in peptic ulcer treatment and prevention, both in ayurveda and Western medicine.

Section: Ulcer Treatmentmentioning

confidence: 99%

A Study of Various Medicinal Plants used in Ulcer Treatment: A Review

Awuchi

Saha

Amle

et al. 2023

“…Method validation involves assessing several parameters, including linearity, limit of detection, limit of quantification, specificity, robustness, and ruggedness, among others. By validating the method, the analyst can ensure that the method is fit for the intended purpose and that the results obtained are reliable and reproducible [28].…”

Section: Accuracymentioning

confidence: 99%

A Comprehensive Review on Analytical Method Development using RP-HPLC and Recent Advances in Pharmaceutical Applications

Kumar¹,

Kumar²,

Kumar³

et al. 2023

The analytical technique of choice for separating, identifying, and quantifying complex mixtures is high-performance liquid chromatography (HPLC). Reverse-phase liquid chromatography (RP-HPLC) is the preferred separation mode for high-performance liquid chromatography (HPLC) due to its adaptability and higher selectivity for hydrophobic compounds. This review article discusses the fundamentals of reversed-phase high-performance liquid chromatography (RP-HPLC). This covers the separation principle, various stationary and mobile phase types, and separation-affecting variables. This article highlights the need of developing and testing such methods in addition to outlining the advantages of using RP-HPLC in industries like pharmaceutical, food, and environmental analysis. As examples of more recent advancements in RP-HPLC, new stationary and mobile phases, RP-HPLC downsizing, and hyphenated methods are also discussed. This review article provides a comprehensive tool for designing, refining, and validating RP-HPLC processes.

“…Precision Olfactory Delivery (POD®) by Impel Neuropharma is an aerosol medication delivery system designed to improve N-to-B drug delivery. This gadget employs pressured gas instead of the patient's exhalation force to release the dose [6,9,10]. Manufacturers claim a 50% deposition in the nasal cavity, and it comes with a tank of compressed air or nitrogen, chlorofluorocarbon (CFC), or hydrofluoroalkane (HFA) used as a propellant and air chamber [111].…”

Section: Device For Nose To Brain Deliverymentioning

confidence: 99%

“…It can also reduce the drug's solubility, absorption rate, and extension. Therefore, substantial dosages must be administered to obtain plasmatic therapeutic concentrations, leading to both drug waste and perhaps an increase in side effects and drug-drug or food-drug interactions [10].…”

Section: Introductionmentioning

confidence: 99%

Recent Advancement in Self Emulsifing Drug Delivery System

Bist

Faruk

2023

Every day, researchers make new attempts to identify neurotherapeutics, but few of them make it to clinical trials. The main cause is their low bioavailability, which is connected to low water solubility, low permeability through biological membranes, and the hepatic first-pass metabolism. However, the most significant challenge in administering drugs to the brain is overcoming the blood-brain barrier. In order to get around it, intranasal administration has become more popular, sometimes even more so than oral administration. Because of its structure, the nasal cavity can bypass the blood-brain barrier and transport drugs to the brain directly. Nasal absorption increases the systemic bioavailability of highly processed substances because they bypass the hepatic first-pass metabolism. However, due to their unique physicochemical properties, most neurotherapeutics must be synthesized in lipidic nanosystems as self-emulsifying drug delivery systems (SEDDS). To load large quantities of lipophilic medicines into micro or nanoemulsions, these isotropic mixes of oils, surfactants, and co-surfactants are diluted in water. The goal of SEDDS is to increase the stability of labile pharmaceuticals against enzymatic activity, boost drug penetration through absorptive membranes, and reduce the likelihood of drug precipitation at absorption sites. Therefore, improved brain targeting and bioavailability of medications might be anticipated by combining the benefits of SEDDS with those of the intranasal route for brain delivery. In order to better understand the mechanisms involved in the intranasal administration of pharmaceuticals loaded in SEDDS, this paper provides a comprehensive characterization of SEDDS as a lipidic nanosystem. Finally, the in vivo effects of intranasal or oral delivery of SEDDS, showing their superiority over standard solutions or suspensions, are described.