Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

Matos, Leandro Luongo de; Sanábria, Álvaro; Robbins, K. Thomas; Halmos, György B.; Strojan, Primož; Ng, Wai Tong; Takes, Robert P.; Angelos, Peter; Piazza, Cesare; Bree, Remco de; Ronen, Ohad; Guntinas‐Lichius, Orlando; Eisbruch, Avraham; Zafereo, Mark; Mäkitie, Antti; Shaha, Ashok R.; Coca‐Pelaz, Andrés; Rinaldo, Alessandra; Saba, Nabil F.; Cohen, Oded; López, Fernándo; Rodrigo, Juan P.; Silver, Carl E.; Strandberg, Timo; Kowalski, Luiz Paulo; Ferlito, Alfio

doi:10.1007/s12325-023-02460-x

Cited by 6 publications

(2 citation statements)

References 110 publications

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“…Furthermore, Mohanti et al reported a partial response rate of 37% in patients with advanced head and neck cancer treated with an RT protocol of 20 Gy delivered in 5 fractions of 4 Gy each over one week (10), while Vargas A. documented significant symptom alleviation in patients with soft tissue tumors treated with a single fraction of RT (11). These studies collectively reinforce the potential of hypofractionated RT to effectively manage pain in this patient population (14)(15)(16).…”

Section: Discussionsupporting

confidence: 62%

Quad Shot Palliation, A Considerable Option for Non-Osseous Recurrent or Metastatic Malignancies in Elderly or Frail Patients.

Saif Ur Rehman,

Shafaq Maqsood,

Aneela Deevan

2024

JHRR

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Background: Palliative radiation therapy (RT) is increasingly recognized as a crucial component of care for patients with advanced, incurable malignancies. In Pakistan, where patients often present at advanced stages due to socio-economic barriers and limited healthcare access, efficient and effective treatment protocols are essential. Objective: This study aimed to evaluate the efficacy of the Quad Shot hypo-fractionated RT protocol for pain palliation in elderly and frail patients with recurrent or metastatic non-osseous malignancies. Methods: A quasi-experimental study was conducted at the Oncology Department of Ganga Ram Hospital, Lahore. Forty-two elderly patients with histologically confirmed inoperable malignancies and a WHO Performance Status of 2 to 3 were enrolled. Patients with prior RT or a second cancer were excluded. RT was delivered using a Cobalt-60 beam, with a total dose of 14 Gy divided into four fractions over two consecutive days. Pain severity was assessed using a 10-point scale before and four weeks after treatment. Statistical analysis was performed using the Wilcoxon Sign Rank Test on SPSS version 25.0. Results: The study population comprised 52% males and 48% females, with the majority of primary tumors located in the head and neck (64%). Post-treatment, the mean pain score significantly decreased from 8.04 ± 1.22 to 4.32 ± 0.89 (p < 0.05). Conclusion: The Quad Shot hypo-fractionated RT protocol effectively reduces pain in elderly and frail patients with advanced malignancies, suggesting its suitability as a quick and effective palliative care option in resource-limited settings.

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Section: Discussionsupporting

confidence: 62%

Quad Shot Palliation, A Considerable Option for Non-Osseous Recurrent or Metastatic Malignancies in Elderly or Frail Patients.

Saif Ur Rehman,

Shafaq Maqsood,

Aneela Deevan

2024

JHRR

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“…Few studies have been done to predict quality of life based on questionnaires using advanced machine learning. Predicting quality of life helps identify patients at higher risk of negative impacts, enabling targeted interventions like psychological support or symptom management strategies for those needing additional assistance [33][34][35][36]. We aim to predict the quality of life using light gradient Boost Tree classifiers based on questionnaires from oral cancer patients.…”

Section: Background and Introductionmentioning

confidence: 99%

Light gradient boosting-based prediction of quality of life among oral cancer-treated patients

Ramalingam,

Yadalam,

Ramani

et al. 2024

BMC Oral Health

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Background and introduction Statisticians rank oral and lip cancer sixth in global mortality at 10.2%. Mouth opening and swallowing are challenging. Hence, most oral cancer patients only report later stages. They worry about surviving cancer and receiving therapy. Oral cancer severely affects QOL. QOL is affected by risk factors, disease site, and treatment. Using oral cancer patient questionnaires, we use light gradient Boost Tree classifiers to predict life quality. Methods DIAS records were used for 111 oral cancer patients. The European Organisation for Research and Treatment of Cancer’s QLQ-C30 and QLQ-HN43 were used to document the findings. Anyone could enroll, regardless of gender or age. The IHEC/SDC/PhD/OPATH-1954/19/TH-001 Institutional Ethical Clearance Committee approved this work. After informed consent, patients received the EORTC QLQ-C30 and QLQ-HN43 questionnaires. Surveys were in Tamil and English. Overall, QOL ratings covered several domains. We obtained patient demographics, case history, and therapy information from our DIAS (Dental Information Archival Software). Enrolled patients were monitored for at least a year. After one year, the EORTC questionnaire was retaken, and scores were recorded. This prospective analytical exploratory study at Saveetha Dental College, Chennai, India, examined QOL at diagnosis and at least 12 months after primary therapy in patients with histopathologically diagnosed oral malignancies. We measured oral cancer patients’ quality of life using data preprocessing, feature selection, and model construction. A confusion matrix was created using light gradient boosting to measure accuracy. Results Light gradient boosting predicted cancer patients’ quality of life with 96% accuracy and 0.20 log loss. Conclusion Oral surgeons and oncologists can improve planning and therapy with this prediction model.

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The need to include older patients with head and neck cancer in clinical trials

Matos,

Kowalski

2024

The Lancet Healthy Longevity

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Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

Cited by 6 publications

References 110 publications

Quad Shot Palliation, A Considerable Option for Non-Osseous Recurrent or Metastatic Malignancies in Elderly or Frail Patients.

Quad Shot Palliation, A Considerable Option for Non-Osseous Recurrent or Metastatic Malignancies in Elderly or Frail Patients.

Light gradient boosting-based prediction of quality of life among oral cancer-treated patients

The need to include older patients with head and neck cancer in clinical trials

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