Management of orofacial lesions with antimicrobial photodynamic therapy and photobiomodulation protocols in patients with COVID-19: A multicenter case series

Sachet, Paula; Rocha, Breno Amaral; Lima, Fabianne Soares; Pedrosa, Marlus da Silva; Guollo, André; Filho, Mário Rodrigues de Melo; Horta, Martinho Campolina Rebello; Simões, Alyne

doi:10.1016/j.pdpdt.2022.102743

Cited by 11 publications

(22 citation statements)

References 6 publications

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“…The anti-inflammatory and antipyretic drugs include dipyrone, 83 , 113 acetaminophen, 90 , 96 , 101 , 119 , 132 ibuprofen, 81 acetylsalicylic acid, 77 paracetamol 73 , 95 , 101 Steroids also prescribe dexamethasone, 77 , 111 , 113 prednisone 77 and methylprednisolone. 100 Other types of drugs include proton pump inhibitors, 91 anti-malaria, 73 , 95 , 116 anti-virus, 73 , 100 , 116 antihistamine, 90 mucolytic, 77 , 101 , 111 anticholinergic, 77 anti-coagulant, 95 , 96 , 100 , 111 antiparasitic, 126 anti-gout, 111 anti-gerd, 111 anti-depressant 110 , 111 and multivitamin 73 , 81 , 91 , 95 , 101 , 105 , 111 ( Table 11 ).…”

Section: Resultsmentioning

confidence: 99%

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

Sarasati¹,

Agustina²,

Surboyo³

2023

IDR

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Objective Many previously reported publications mentioned that oral lesion in COVID-19 patients was varied. The term oral manifestations refer to pathognomonic features that are found consistently with a specific cause and effect. In this context, the oral manifestation of COVID-19 was inconclusive. This systematic review aimed to analyse previously reported publications related to oral lesions in COVID-19 patients to define as oral manifestations or not. The PRISMA guidelines were implemented in this review. Methods All umbrella reviews, systematic reviews, systematic reviews and meta-analyses, comprehensive reviews, and original and non-original studies were included. Twenty-one of systematic review, 32 original studies and 68 non-original studies reported the oral lesion in COVID-19 patients. Results Most of the publications mentioned that ulcers, macular, pseudomembranes and crusts were frequent oral lesions. The reported oral lesions in COVID-19 patients did not show any pathognomonic features and might be unrelated directly to COVID-19 infections, however, more likely due to gender, age, underlying diseases, and medication. Conclusion The oral lesions found in previous studies do not have pathognomonic features and are inconsistent. Therefore, the reported oral lesion, in present time, cannot be defined as an oral manifestation.

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Section: Resultsmentioning

confidence: 99%

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

Sarasati¹,

Agustina²,

Surboyo³

2023

IDR

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“…Antiviral PDI is not yet an established method in the clinical setting and, as by now, is mostly limited to topical applications. Recent reports suggest, however, that antiviral PDI has been successfully used in the clinical setting, e.g., for oral decontamination [45] and treatment of orofacial manifestations [46] in patients suffering from COVID-19. In these reports, clinically approved agents, like methylene blue or curcumin, are used as photosensitizers, although their properties are far from optimal.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In Vitro

Ziganshyna

Szczepankiewicz

Kuehnert

et al. 2022

Viruses

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Despite available vaccines, antibodies and antiviral agents, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic still continues to cause severe disease and death. Current treatment options are limited, and emerging new mutations are a challenge. Thus, novel treatments and measures for prevention of viral infections are urgently required. Photodynamic inactivation (PDI) is a potential treatment for infections by a broad variety of critical pathogens, including viruses. We explored the infectiousness of clinical SARS-CoV-2 isolates in Vero cell cultures after PDI-treatment, using the photosensitizer Tetrahydroporphyrin-tetratosylate (THPTS) and near-infrared light. Replication of viral RNA (qPCR), viral cytopathic effects (microscopy) and mitochondrial activity were assessed. PDI of virus suspension with 1 µM THPTS before infection resulted in a reduction of detectable viral RNA by 3 log levels at day 3 and 6 after infection to similar levels as in previously heat-inactivated virions (<99.9%; p < 0.05). Mitochondrial activity, which was significantly reduced by viral infection, was markedly increased by PDI to levels similar to uninfected cell cultures. When applying THPTS-based PDI after infection, a single treatment had a virus load-reducing effect only at a higher concentration (3 µM) and reduced cell viability in terms of PDI-induced toxicity. Repeated PDI with 0.3 µM THPTS every 4 h for 3 d after infection reduced the viral load by more than 99.9% (p < 0.05), while cell viability was maintained. Our data demonstrate that THPTS-based antiviral PDI might constitute a promising approach for inactivation of SARS-CoV-2. Further testing will demonstrate if THPTS is also suitable to reduce the viral load in vivo.

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“…Since photobiomodulation therapy (PBMT) and APDT can be used to inactivate the virus, reduce inflammation, reduce pain, and repair tissue in these lesions associated with COVID-19 [170] , Sachet et al. [171] investigated the therapeutic results of PBMT/APDT methods. Since these lesions are caused by SARS-CoV-2, it is better to initiate APDT during the first 1–2 d of treatment.…”

Section: Physical Stimuli-responsive Systemsmentioning

confidence: 99%

Smart stimuli-responsive drug delivery systems in spotlight of COVID-19

Najjari,

Sadri,

Varshosaz

2023

Asian Journal of Pharmaceutical Sciences

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Management of orofacial lesions with antimicrobial photodynamic therapy and photobiomodulation protocols in patients with COVID-19: A multicenter case series

Cited by 11 publications

References 6 publications

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In Vitro

Smart stimuli-responsive drug delivery systems in spotlight of COVID-19

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