Management of otitis media with effusion in children with primary ciliary dyskinesia: A literature review

Campbell, Raewyn; Birman, Catherine S.; Morgan, Lucy

doi:10.1016/j.ijporl.2009.08.024

Cited by 55 publications

(41 citation statements)

References 57 publications

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“…The Consensus statement indicates that the strength of this recommendation is ''strong'' yet the level of evidence is ''low.'' The evidence surrounding this issue has been thoroughly and critically reviewed by Campbell and colleagues (28). However, the evidence does not strongly endorse the recommendation against ventilation tube insertion.…”

Section: Otolaryngologic Manifestations Of Pcdmentioning

confidence: 99%

Update of Respiratory Tract Disease in Children with Primary Ciliary Dyskinesia

Sagel¹,

Davis²,

Campisi³

et al. 2011

Proceedings of the American Thoracic Society

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Primary ciliary dyskinesia (PCD) is a rare genetic disease characterized by abnormal ciliary structure and function leading to impaired mucociliary clearance and chronic progressive sinopulmonary disease. Upper and lower respiratory tract manifestations are cardinal features of PCD. This review summarizes the current state of knowledge of respiratory tract disease in individuals with PCD and highlights the challenges in identifying and quantifying lung disease in very young children with PCD. No specific therapies are available to correct ciliary dysfunction in PCD. Treatment is not evidence based, and recommendations are largely extrapolated from cystic fibrosis and other conditions with impaired mucociliary clearance. There is a pressing need to develop and validate outcome measures, including patient-reported outcomes, that could be used to evaluate potential therapies in PCD. This review concludes with recommendations for clinical endpoints and outcome measures and a prioritized list of treatments to study in PCD clinical trials.

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Section: Otolaryngologic Manifestations Of Pcdmentioning

confidence: 99%

Update of Respiratory Tract Disease in Children with Primary Ciliary Dyskinesia

Sagel¹,

Davis²,

Campisi³

et al. 2011

Proceedings of the American Thoracic Society

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“…Outcome measures are rarely defined and mostly derived from a limited number of old retrospective studies with few patients [8,[68][69][70].…”

Section: Upper Airway Managementmentioning

confidence: 99%

“…Current options include antibiotic therapy, hearing aids and myringotomy with or without insertion of ventilation tubes (VTs), with the main debate revolving around the latter [8]. The European consensus guidelines advised against VT use in children, based on low-level evidence derived from small studies reporting offensive otorrhoea after surgery [8,48].…”

Section: Upper Airway Managementmentioning

confidence: 99%

Clinical care for primary ciliary dyskinesia: current challenges and future directions

Rubbo

Lucas

2017

Eur Respir Rev

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Primary ciliary dyskinesia (PCD) is a rare genetic disease that affects the motility of cilia, leading to impaired mucociliary clearance. It is estimated that the vast majority of patients with PCD have not been diagnosed as such, providing a major obstacle to delivering appropriate care. Challenges in diagnosing PCD include lack of disease-specific symptoms and absence of a single, "gold standard", diagnostic test. Management of patients is currently not based on high-level evidence because research findings are mostly derived from small observational studies with limited follow-up period. In this review, we provide a critical overview of the available literature on clinical care for PCD patients, including recent advances. We identify barriers to PCD research and make suggestions for overcoming challenges.

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“…Otozomal resesif geçişli değişken penetranslı silya hareket bozukluğuna ikincil gelişen mukosiliyer klerenste azalma ile karakterize genetik bir hastalıktır, önceleri immotil silya sendromu olarak tanımlanmıştır (34,35). Kartagener sendromu primer siliyer diskinezili hastaların %50'sinde görülüp rinosinüzit, bronşektazi ve situs inversus triadıyla karakterizedir.…”

Section: Primer Siliyer Diskineziunclassified

“…İşitme seviyeleri sadece VT'nün kulakta kaldığı süre içinde iyi olduğu için çocukların dil gelişiminden sonra VT tatbikinin faydası yok gibi gözükmektedir. Primer siliyer diskinezili çocuklar-da kronik EOM'nın cerrahi tedavisinin yararı kanıta dayalı bilgi olarak dördüncü seviyede kaldığından klinik pratikte uygulanması gereken kesin bir algoritmaya ihtiyaç vardır (35).…”

Section: Primer Siliyer Diskineziunclassified

Ventilation tubes and indications

2016

Anatolian J Med Sci

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Management of otitis media with effusion in children with primary ciliary dyskinesia: A literature review

Cited by 55 publications

References 57 publications

Update of Respiratory Tract Disease in Children with Primary Ciliary Dyskinesia

Update of Respiratory Tract Disease in Children with Primary Ciliary Dyskinesia

Clinical care for primary ciliary dyskinesia: current challenges and future directions

Ventilation tubes and indications

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