Management of Ovarian Stromal Cell Tumors

Colombo, Nicoletta; Parma, Gabriella; Zanagnolo, Vanna; Insinga, Alessandra

doi:10.1200/jco.2007.11.1005

Cited by 292 publications

(309 citation statements)

References 60 publications

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“…Multiple granulosa cell dysfunctions lead to disordered ovulatory and ovarian function [1]. Moreover, granulosa cell tumors (GCTs) are serious ovarian neoplasms that can occur in women of all ages [2]. As most malignant ovarian tumors are epithelial in origin, most studies of ovarian cancer do not include GCTs [3].…”

Section: Introductionmentioning

confidence: 99%

Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells

Huang

Cheng

Nishi³

et al. 2010

Reprod Biol Endocrinol

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BackgroundHomeobox (HOX) genes encode transcription factors, which regulate cell proliferation, differentiation, adhesion, and migration. The deregulation of HOX genes is frequently associated with human reproductive system disorders. However, knowledge regarding the role of HOX genes in human granulosa cells is limited.MethodsTo determine the role of HOXA7 in the regulation and associated mechanisms of cell proliferation in human granulosa cells, HOXA7 and epidermal growth factor receptor (EGFR) expressions were examined in primary granulosa cells (hGCs), an immortalized human granulosa cell line, SVOG, and a granulosa tumor cell line, KGN, by real-time PCR and Western blotting. To manipulate the expression of HOXA7, the HOXA7 specific siRNA was used to knockdown HOXA7 in KGN. Conversely, HOXA7 was overexpressed in SVOG by transfection with the pcDNA3.1-HOAX7 vector. Cell proliferation was measured by the MTT assay.ResultsOur results show that HOXA7 and EGFR were overexpressed in KGN cells compared to hGCs and SVOG cells. Knockdown of HOXA7 in KGN cells significantly decreased cell proliferation and EGFR expression. Overexpression of HOXA7 in SVOG cells significantly promoted cell growth and EGFR expression. Moreover, the EGF-induced KGN proliferation was abrogated, and the activation of downstream signaling was diminished when HOXA7 was knocked down. Overexpression of HOXA7 in SVOG cells had an opposite effect.ConclusionsOur present study reveals a novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via the regulation of EGFR. This finding contributes to the knowledge of the pro-proliferation effect of HOXA7 in granulosa cell growth and differentiation.

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Section: Introductionmentioning

confidence: 99%

Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells

Huang

Cheng

Nishi³

et al. 2010

Reprod Biol Endocrinol

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“…There are no data to support any kind of postoperative adjuvant treatment for patients with stage I GCTs, given the indolent nature of these neoplasms and the overall good prognosis [11]. One of the patients was classified as FIGO 1c after restaging.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that patients with stage I disease who underwent adequate staging procedure have a very low risk of recurrence [11]. If disease was not staged at first surgery, a restaging intervention should be performed.…”

Section: Discussionmentioning

confidence: 99%

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Laparoscopic restaging of ovarian granulosa cells tumor: three cases report

et al. 2008

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Granulosa cell tumor (GCT) of the ovary is an uncommon neoplasm, often diagnosed at an early stage. Surgery is necessary for definitive diagnosis and staging. Complete staging is recommended as for epithelial ovarian cancer and a restaging procedure is sometime required. The staging procedure should include evaluation of para-aortic and pelvic lymph nodes. We report three cases of laparoscopic restaging of GCT. The patients were treated in our Institution from August 2005 to January 2007. They were diagnosed an ovarian cyst and underwent laparoscopic adnexectomy. Histology showed a GCT (one case of juvenile type in a 38-year-old woman). All the patients were submitted to laparoscopic restaging with pelvic and para-aortic lymphadenectomy. Mean operation time was 195 min. A mean number of 32 lymph nodes were removed. No major intraoperative or postoperative complication occurred. Patients were discharged on the second or third postoperative day. All the patients are well and without disease. Laparoscopic restaging of GCT is feasible and allows para-aortic and pelvic lymphadenectomy. Patients restaged by laparoscopy benefit of a less invasive treatment.

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“…If metastatic, adequate cytoreduction is the mainstay of treatment. If the patient is young and the disease is confined to one ovary, conservative surgery should be performed [96,97].…”

Section: Management Of Granulosa Cell Tumorsmentioning

confidence: 99%