2022
DOI: 10.1080/00325481.2022.2035092
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Management of pain using magnesium sulphate: a narrative review

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Cited by 25 publications
(7 citation statements)
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“…Likewise, the cerebral contusion in vivo models revealed the efficacy of magnesium sulfate for combating neuronal cell death and edema [ 16 , 18 ]. In addition, it has also been reported that magnesium sulfate is competent to lessen pain in experimental animal models [ 19 ]. Of note, magnesium sulfate has been characterized to gain access to brain regions by penetrating the blood-brain barrier, particularly under brain pathological conditions [ 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…Likewise, the cerebral contusion in vivo models revealed the efficacy of magnesium sulfate for combating neuronal cell death and edema [ 16 , 18 ]. In addition, it has also been reported that magnesium sulfate is competent to lessen pain in experimental animal models [ 19 ]. Of note, magnesium sulfate has been characterized to gain access to brain regions by penetrating the blood-brain barrier, particularly under brain pathological conditions [ 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…This concept is based on utilizing different groups of pain medications for additive and/or synergistic effects and results in reduction of side effects of larger doses of each medication seen for example with administration of only large amounts of opioids (7,15). Multiple adjuvant drugs have been identified through clinical studies, including ketamine, NSAIDs, gabapentin, paracetamol, intravenous lidocaine, and magnesium (16)(17)(18)(19). Adjuvants medications that provide enhanced local anesthetic duration of activity include dexamethasone, alpha-2 agonists such as dexmedetomidine and clonidine, NMDA antagonists such as ketamine, neostigmine, epinephrine, and sodium bicarbonate (20)(21)(22)(23)(24).…”
Section: Resultsmentioning
confidence: 99%
“…It is seen as effective without sacrificing the element of safety. It should be mentioned that studies on additional neuroprotective substances, such as melatonin, are now underway [52][53][54].…”
Section: Complications Associated With Mgso4mentioning
confidence: 99%