Management of parvovirus infection in pregnancy and outcomes of hydrops: A survey of members of the Society of Perinatal Obstetricians

Hydrops Fetalis Secondary to Parvovirus B19 Infections

“…The risk of fetal death appears to be higher in fetuses managed expectantly than in those managed with intrauterine transfusion. Rodis et al 8 recently reported the outcomes of 539 cases of parvovirus-induced hydrops. The study showed survival of 83.5% of hydropic fetuses that were transfused, whereas, in general, nonimmune fetal hydrops has been associated with mortality rates ranging from 50% to 98%.…”

“…With intrauterine transfusions, several authors have reported improved outcomes in cases of moderate anemia caused by hydrops. 8 We report two cases of maternal parvovirus infection with the classic finding of hydrops fetalis. Serologic evidence of parvovirus-specific IgMantibody positivity confirmed the diagnosis.…”

Neurodevelopmental outcome after intrauterine red cell transfusion for Parvovirus B19-induced fetal hydrops

“…Management with intrauterine transfusion (IUT) can correct fetal anaemia and may reduce the mortality of fetal Parvovirus B19 infection significantly. Fetal mortality rate due to Parvovirus B19-induced hydrops has been reported as high as 30% without IUT 5,6 . Management with IUT guided by appropriate anaemia Z-scores in the absence of fetal myocarditis may reduce mortality by more than 50% 5 .…”

Avaliação longitudinal da infecção por parvovírus B19 entre grávidas em Ribeirão Preto, SP, Brasil

“…Há relatos demonstrando que a transfusão sangüínea intraútero, intra-peritoneal ou por cordocentese é o tratamento de escolha para hidropisia e/ou anemia fetal causadas pela infecção pelo PB19 11,12 . Outros autores relatam que a espera pela cura espontânea seria a medida mais correta, com maior chance de resolução do caso e menores riscos para o feto 13 .…”