Exercise is complementary to cancer prevention, care, and survivorship. Exercise is considered safe and effective during and after cancer treatment when conducted under supervision and in controlled environments. Less is known about the safety and effectiveness of unsupervised, home-based exercise programs. Implementing methods of monitoring and reporting can provide more information and potentially enhance exercise effects and program integrity. This paper describes the development of REMEDY, a remote monitoring sensor system consisting of a wireless body-area network (WBAN), cloud database, mobile assisted application, and a set of intelligent algorithms. REMEDY can provide real-time exercise monitoring, participant feedback, and quality assessment that may lead to safer and more effective exercise programs and exercises for cancer patients and survivors.