Management of Patients with Head and Neck Tumours Presenting at Diagnosis with a Synchronous Second Cancer at Another Anatomic Site

Gräff, P.; Schipman, B.; Désandes, Emmanuel; Mecellem, Hinda; Toussaint, B.; Cortese, Sophie; Marchal, Frédéric; Kaminsky, Marie‐Christine; Geoffrois, Lionnel; Peiffert, D.

doi:10.1016/j.clon.2010.10.008

Cited by 15 publications

(21 citation statements)

References 16 publications

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“…This was also noted by Wang, Lee, et al This discrepancy could indicate that without an active screening program, esophageal‐SPTs are underdiagnosed in patients with HNSCC . Multiple studies state that the occurrence of esophageal‐SPTs negatively influences patient survival, especially in patients with advanced esophageal‐SPTs . Some researchers even claim that SPTs are the leading cause of treatment failure and death in patients with HNSCC …”

Section: Discussionmentioning

confidence: 81%

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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Background Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy. Methods A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies. Results Fifteen studies with a total of 3386 patients were included. The average yield of esophageal‐SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal‐SPTs were classified as high‐grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%. Conclusion Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal‐SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.

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Section: Discussionmentioning

confidence: 81%

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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“…Graff et al have shown that a synchronous primary with high staged index tumor in the head and neck region and with esophageal involvement carries a poor prognosis, so identification of the presence or occurrence of synchronous primary with a low stage tumor and without esophageal involvement could most benefit from an aggressive form of treatment. [28] This can be achieved by doing UGIE to rule out the esophageal involvement. In our analysis, majority of synchronous cancers occurred with the higher staged (Stage III and Stage IV) index tumor, which is 64% of the total and in almost 65% of esophageal synchronous cancer there were associated Stage III and Stage IV index tumor.…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients

et al. 2013

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“…Although these patients belong to a complex group, if their clinical general conditions allow it, an aggressive loco-regional treatment would be indicated [15].…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of second primary tumors in head and neck cancer

Patrucco¹,

Aramendi²

2015

Eur Arch Otorhinolaryngol

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The incidence of Second Primary Tumors in the upper aerodigestive tract varies from 5 to 30 %. Most of them are located either in the same anatomical region or in the lungs, and are related to a poor overall survival. Our objective is to assess the incidence of Second Primary Tumors, factors related to its outcome, frequent associations, and impact on overall survival. 27 patients with Second Primary Tumors were reviewed out of 307 with head and neck cancer, between 2002 and 2011. Patients had a minimum follow-up period of 3 years, or until their death after the last treatment. Sex: 85.2 % were male; male:female ratio of 23:4. The mean age of appearance for the primary tumor was 66.8 years. Only 1 patient had a synchronous Second Primary Tumor, while 26 had metachronous Second Primary Tumors. Second neoplasms were grouped into synchronous and metachronous for statistical analysis. The following parameters were considered: age at diagnosis of the first tumor, gender, smoking and persistence of the habit, primary tumor's location in the larynx, association between two squamous cell carcinomas (index and second primary tumor), and radiotherapy for the primary tumor. The incidence of Second Primary Tumors was 8.79 %. Overall survival of metachronous tumors was 95 months (7.9 years). The primary tumor's location that prevailed when developing a Second Primary Tumor was the larynx. Regarding the histology, the most common association was head and neck squamous cell carcinoma with head and neck squamous cell carcinoma (9 patients). The Second Primary Tumor was the cause of death in 51.9 % of the patients and its most frequent location was the lungs. 19 patients underwent radiotherapy. Second Primary Tumors are common in the head and neck. The authors would like to enforce the importance of an extended follow-up, since second neoplasms worsen considerably the patient's prognosis. Patients who keep on smoking after treatment decrease even more their overall survival.

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Management of Patients with Head and Neck Tumours Presenting at Diagnosis with a Synchronous Second Cancer at Another Anatomic Site

Cited by 15 publications

References 16 publications

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients

Prognostic impact of second primary tumors in head and neck cancer

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