Management of patients with metastatic colorectal cancer in Lebanese hospitals and associated direct cost: a multicentre cohort study

Hénaine, Anna Maria; Chahine, Georges; Massoud, Marcel; Salameh, Pascale; Awada, Sanaa; Lahoud, Nathalie; Elias, E. John; Salem, Mansour; Ballout, Souheir; Aulagner, G.; Armoiry, Xavier

doi:10.26719/emhj.18.063

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…49 It is worth noting as well that the mean global total cost for the treatment of metastatic CRC in Lebanese hospitals was found to be USD 64,805 per patient. 50 This is significant, knowing that 21.9% of CRC cases studied in a tertiary care center in Lebanon were metastatic at the time of diagnosis. 51 Also, the medications used for CRC are among the 4 cancer types consuming up to 67% of the MoPH oncology drug budget in 2008-2013 (breast cancer followed by chronic myeloid leukemia, CRC, and lung cancer).…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer in Lebanon: Incidence, Temporal Trends, and Comparison to Regional and Western Countries

2021

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Global trends in the incidence and mortality rates of colorectal cancer show a steady increase with significant predilection to western developed countries, possibly linking it to westernized lifestyles among other risk factors. This study aims to investigate the incidence and trends of colorectal cancer in Lebanon, a country in the Middle East and North Africa region, and to compare these rates to those in regional and western countries. Colorectal cancer incidence data were extracted from the Lebanese National Cancer Registry for the currently available years 2005 to 2016. The calculated age-standardized incidence rates and age-specific rates were expressed as per 100,000 population. The age-standardized incidence rates of colorectal cancer in Lebanon increased from 16.3 and 13.0 per 100,000 in 2005 to 23.2 and 20.2 per 100,000 in 2016, among males and females, respectively. The incidences were higher for males, and they increased with age. The annual percent change was +4.36% and +4.45%, in males and females respectively (p-value < 0.05). There was a non-statistically significant trend of decrease in recent years (since 2012 in males and since 2011 in females). The age-standardized incidence rates in Lebanon were higher than those in the majority of the regional countries, but lower than the rates in developed western countries. There were high age-specific incidence rates at age groups 40-44 and 45-49 years in Lebanon in both males and females (with significant rising temporal trend) compared to other countries, including the ones reported to have the highest colorectal cancer age-standardized incidence rate worldwide. Therefore, the burden of colorectal cancer is significant in Lebanon. This raises the necessity to develop national strategies tailored to reduce colorectal cancer incidence through promoting healthy lifestyles, raising awareness, and early detection as of 40 years of age.

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Section: Discussionmentioning

confidence: 99%

Colorectal Cancer in Lebanon: Incidence, Temporal Trends, and Comparison to Regional and Western Countries

2021

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“…Notably, CRC is now the third most prevalent cancer worldwide and has risen to become the second leading cause of cancer-related death [ 5 , 6 ]. The steady increase in CRC incidence could place a substantial public health burden on society and challenge the development of a sustainable healthcare system, as considerable medical resources would be required for cancer treatment [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The investigation of constraints in implementing robust AI colorectal polyp detection for sustainable healthcare system

2023

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Colorectal cancer (CRC) is one of the significant threats to public health and the sustainable healthcare system during urbanization. As the primary method of screening, colonoscopy can effectively detect polyps before they evolve into cancerous growths. However, the current visual inspection by endoscopists is insufficient in providing consistently reliable polyp detection for colonoscopy videos and images in CRC screening. Artificial Intelligent (AI) based object detection is considered as a potent solution to overcome visual inspection limitations and mitigate human errors in colonoscopy. This study implemented a YOLOv5 object detection model to investigate the performance of mainstream one-stage approaches in colorectal polyp detection. Meanwhile, a variety of training datasets and model structure configurations are employed to identify the determinative factors in practical applications. The designed experiments show that the model yields acceptable results assisted by transfer learning, and highlight that the primary constraint in implementing deep learning polyp detection comes from the scarcity of training data. The model performance was improved by 15.6% in terms of average precision (AP) when the original training dataset was expanded. Furthermore, the experimental results were analysed from a clinical perspective to identify potential causes of false positives. Besides, the quality management framework is proposed for future dataset preparation and model development in AI-driven polyp detection tasks for smart healthcare solutions.

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Cancer research in Lebanon: Scope of the most recent publications of an academic institution (Review)

Tawil,

Khaddage-Soboh

2024

Oncol Lett

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Cancer may be considered one of the most interesting areas of study, and although oncology research has grown markedly over the last decade, there is as yet no known cure for cancer. The objective of the present review is to examine various approaches to cancer research from a single institution, summarize their key conclusions and offer recommendations for future evaluations. The review examined 72 cancerassociated studies that were published within six years from 2017 to 2022. Published works in the subject fields of 'cancer' or 'oncology' and 'research' that were indexed in Scopus and Web of Science were retrieved and sorted according to article title, author names, author count, citation count and key words. After screening, a total of 28 in vitro/animal studies and 46 patient-associated published studies were obtained. A large proportion of these studies comprised literature reviews (20/72), while 20 studies were observational in nature. The 72 publications included 23 in which various types of cancer were examined, while the remaining studies focused on specific types of cancer, including lung, breast, colon and brain cancer. These studies aimed to investigate the incidence, prevalence, treatment and prevention mechanisms associated with cancer. Despite the existence of extensive cancer research, scientists seldom contemplate an ultimate cure for cancer. However, it is crucial to continuously pursue research on cancer prevention and treatment in order to enhance the effectiveness and minimize potential side effects of cancer therapy. Contents1. Introduction 2. Study retrieval 3. Study design and setting 4. Types of cancer and main endpoint 5. Detailed description of LAU cancer studies 6. Principal findings 7. Significance of the study and future implications for policy and practice 8. Conclusions

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Management of patients with metastatic colorectal cancer in Lebanese hospitals and associated direct cost: a multicentre cohort study

Cited by 3 publications

References 42 publications

Colorectal Cancer in Lebanon: Incidence, Temporal Trends, and Comparison to Regional and Western Countries

Colorectal Cancer in Lebanon: Incidence, Temporal Trends, and Comparison to Regional and Western Countries

The investigation of constraints in implementing robust AI colorectal polyp detection for sustainable healthcare system

Cancer research in Lebanon: Scope of the most recent publications of an academic institution (Review)

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