Management of perimenopause disorders: hormonal treatment

Troìa, Libera; Martone, Simona; Morgante, Giuseppe; Luisi, Stefano

doi:10.1080/09513590.2020.1852544

Cited by 19 publications

(11 citation statements)

References 49 publications

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“…During perimenopause, a decline in the levels of estradiol is generally seen with an increase in the levels of FSH and LH; thus, resulting in the hypothalamic-pituitary-ovarian axisrelated disorders. 30 Ashwagandha root extract supplementation leads to a statistically significant increase in the level of estradiol, which explains the positive effect of the supplement. Studies 31,32 indicate that higher concentrations of estradiol are necessary to initiate endometrial growth.…”

Section: Discussionmentioning

confidence: 92%

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind, placebo‐controlled study

Gopal

Ajgaonkar

Kanchi

et al. 2021

J of Obstet and Gynaecol

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Background: Perimenopause is the period during which many physiological changes mark the transition into the final menstrual period of a woman and these changes are associated with climacteric symptoms.Objectives: This study aimed to assess the efficacy and tolerability of an Ashwagandha root extract on the climacteric symptoms, quality of life (QoL), and hormonal parameters in perimenopausal women. Materials and Methods: In this 8-week, randomized, double-blind, placebo-controlled study, 100 women with climacteric symptoms were randomly allocated to take either a placebo or 300 mg of an Ashwagandha root extract twice daily. Outcomes were measured using the menopause rating scale (MRS), menopausespecific QoL (MENQoL), hot flash score, and hormonal changes in estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone. Results: Among 100 participants enrolled, 91 participants completed the study. In comparison with the placebo, ashwagandha supplementation was associated with a statistically significant reduction in total MRS score (p < 0.0001), reflected by significant reductions in the psychological (p = 0.0003), somato-vegetative (p = 0.0152), and urogenital (p < 0.0001) domains. Ashwagandha intake demonstrated a statistically significant reduction in total MENQoL scores (p < 0.0001) and was also associated with a statistically significant increase in serum estradiol (p < 0.0001) and a significant reduction in serum FSH (p < 0.0001) and serum LH (p < 0.05) compared with the placebo. There was no significant between the group differences in the serum testosterone level. Conclusion: These findings suggest that ashwagandha root extract can be a safe and effective option to relieve mild to moderate climacteric symptoms during perimenopause in women.

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Section: Discussionmentioning

confidence: 92%

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind, placebo‐controlled study

Gopal

Ajgaonkar

Kanchi

et al. 2021

J of Obstet and Gynaecol

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“…The incidence of perimenopausal depression has increased to a very high rate that cannot be ignored. Although various mechanisms are suggested for the PMD process, it seems that ovarian dysfunction might be the key reason that links the factors for PMD ( 162 ). Recently, many studies have evaluated the importance of ovarian dysfunction in the risk of PMD as well as some other complications such as cardiovascular disease ( 163 ).…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine pathogenesis of perimenopausal depression

Qian

et al. 2023

Front. Psychiatry

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With the development of social economics and the increase of working pressure, more and more women are suffering from long-term serious stress and showing symptoms of perimenopausal depression (PMD). The incidence rate of PMD is increasing, and the physical and mental health are seriously affected. However, due to the lack of accurate knowledge of pathophysiology, its diagnosis and treatment cannot be accurately executed. By consulting the relevant literature in recent years, this paper elaborates the neuroendocrine mechanism of perimenopausal depression from the aspects of epigenetic changes, monoamine neurotransmitter and receptor hypothesis, glial cell-induced neuroinflammation, estrogen receptor, interaction between HPA axis and HPG axis, and micro-organism-brain gut axis. The purpose is to probe into new ways of treatment of PMD by providing new knowledge about the neuroendocrine mechanism and treatment of PMD.

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“…Perimenopause represents a delicate transitional period of female life during which physical, emotional, psychological, and social changes mark the progression of women from fertile life to climaterium or reproductive loss, withwide sexual fluctuations until the onset of hypergonadotropic hypogonorrhea ( 22 ). It is generally 45–55 years of age and is an important stage in the transition of women from middle to old age.…”

Section: Discussionmentioning

confidence: 99%

Effects of aerobics training on anxiety, depression and sleep quality in perimenopausal women

2022

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ObjectiveTo investigate the effect of aerobics training on anxiety, depression and sleep disturbance in perimenopausal women.Materials and methodsA total of 289 perimenopausal women with anxiety, depression or sleep disorder in Lishi district of Luliang city were treated with aerobics training. Self-rating anxiety scale, self-rating depression scale and Pittsburgh sleep scale were used to investigate the anxiety, depression and sleep status of perimenopausal women before and after intervention.ResultsAfter aerobics training, the scores of self-rating anxiety scale, self-rating depression scale and Pittsburgh sleep questionnaire were 48.26 ± 6.47, 50.27 ± 6.54 and 10.64 ± 4.38, respectively. The levels of anxiety, depression and sleep disorder in 289 subjects were significantly lower than those before intervention (t = 3.865, 4.541, 5.596, P < 0.01). The remission rate of symptoms was significantly different in subjects with different frequency of spontaneous practice (P < 0.01), and the higher the number of spontaneous practice, the higher the remission rate of anxiety, depression and sleep disorders in subjects (P < 0.01).Conclusionaerobics training can effectively improve the anxiety and depression of perimenopausal women, improve sleep quality, the more frequency of practice, the more obvious the effect. It can be used as an intervention to improve the mental health level of perimenopausal women in terms of anxiety, depression and sleep quality in clinical promotion.

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Management of perimenopause disorders: hormonal treatment

Cited by 19 publications

References 49 publications

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind, placebo‐controlled study

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind, placebo‐controlled study

Neuroendocrine pathogenesis of perimenopausal depression

Effects of aerobics training on anxiety, depression and sleep quality in perimenopausal women

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