Management of Perineural Invasion in Sebaceous Carcinoma of the Eyelid

Connor, M.; Droll, Lilly; Ivan, Doina; Cutlan, Jonathan E.; Weber, Randal S.; Frank, Steven J.; Esmaeli, Bita

doi:10.1097/iop.0b013e3182163653

Cited by 28 publications

(9 citation statements)

References 24 publications

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“…3 Perineural invasion occurs in approximately 7% of cases. 4 Sebaceous carcinoma has a high recurrence rate, ranging from 6% to 36% of cases. 5 There are multiple risk factors for sebaceous carcinoma including female sex; older age; and white, Indian, or Asian race/ethnicity, immunosuppression, and prior irradiation.…”

Section: Discussionmentioning

confidence: 99%

Enlarging Mass of the Eyelid

Jethwa

Amin

Khariwala

2014

JAMA Otolaryngol Head Neck Surg

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A woman in her 90s presented to her physician with a 2-month history of a mass in her right eyelid that had enlarged to the point that she could no longer open her right eye. The lesion was mildly tender and associated with right submandibular and preauricular lymphadenopathy.Physical examination revealed an approximately 3 × 2-cm tender mass in her right upper eyelid. Examination also revealed a 2-cm, firm, and mobile mid-right parotid mass and a 1-cm, firm, and mobile mass in the parotid tail, both consistent with lymph nodes. There was also ipsilateral level II lymphadenopathy. A contrast-enhanced, computed tomographic image demonstrated an approximately 3.3 × 2.1 × 1.9-cm enhancing lesion in the right upper eyelid ( Figure, A) with invasion of the orbit as well as a 3.0 × 1.6 × 2.4-cm preauricular mass and necrotic lymph nodes in level II.Surgical resection consisted of a right orbital exenteration, right radical parotidectomy, and right neck dissection. Pathologic examination revealed a 3.6 × 3.1 × 3.0-cm grayish white mass. The hematoxylin-eosin photomicrographs (Figure, B and C) demonstrated sheets of neoplastic cells in lobules and nests with prominent hyperchromatic nuclei, vesicular chromatin, occasional mitoses, and finely vacuolated, eosinophilic cytoplasm. The tumor cells stained strongly positive for oil red O (Figure, D). Lymphovascular and perineural invasion was present. Specimens from the parotidectomy and neck dissection revealed metastasis to 25 of 41 lymph nodes. Immunohistochemical staining was not performed in this specimen.

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Section: Discussionmentioning

confidence: 99%

Enlarging Mass of the Eyelid

Jethwa

Amin

Khariwala

2014

JAMA Otolaryngol Head Neck Surg

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“…3,12,27,86,88 In the case of periorbital sebaceous carcinoma, regional lymphadenectomy necessarily includes parotidectomy given the routes of lymphatic drainage of periorbital structures. 68,130,131 In general, the use of radiation therapy for sebaceous carcinoma should be restricted to recurrent lesions, metastatic disease, or palliative treatment in patients who are not candidates for surgical excision. 68,130,131 In general, the use of radiation therapy for sebaceous carcinoma should be restricted to recurrent lesions, metastatic disease, or palliative treatment in patients who are not candidates for surgical excision.…”

Section: Radiationmentioning

confidence: 99%

Sebaceous Carcinoma

Kyllo

Brady

Hurst³

2015

Dermatologic Surgery

122

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“…SGC can exhibit a multicentric pattern of spread, with dispersion into the lacrimal system and nasal cavity. PNI has been reported to occur in up to 7% of cases …”

Section: Malignant Tumors Of the Eyelidmentioning

confidence: 99%

Mohs Micrographic Surgery of the Eyelid: An Overview of Anatomy, Pathophysiology, and Reconstruction Options

Harvey

Taylor

Itani

et al. 2013

Dermatologic Surgery

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Eyelid function is critical for the maintenance of ocular health and vision. MMS is an ideal skin cancer treatment for the delicate structure of the eyelid, where maximal tissue preservation is critical. There are a plethora of reconstruction options to consider after MMS has been performed in this area. The choice of repair and surgical outcome depend, in part, on the surgeon's knowledge of eyelid anatomy and his or her ability to assess the repair requirements of the post-MMS defect. Dermatologic surgeons can effectively work with other specialists to help ensure that their patients receive a cure with restored ocular function and optimal cosmesis.

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Management of Perineural Invasion in Sebaceous Carcinoma of the Eyelid

Cited by 28 publications

References 24 publications

Enlarging Mass of the Eyelid

Enlarging Mass of the Eyelid

Sebaceous Carcinoma

Mohs Micrographic Surgery of the Eyelid: An Overview of Anatomy, Pathophysiology, and Reconstruction Options

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